Comparing Postoperative Recovery and Inflammatory markers in Low vs. Standard Pressure Pneumoperitoneum among Laparoscopic Cholecystectomy Patients.

Phase 4

Conditions: Health Condition 1: K801- Calculus of gallbladder with othercholecystitisHealth Condition 2: K802- Calculus of gallbladder without cholecystitisHealth Condition 3: K802- Calculus of gallbladder without cholecystitisHealth Condition 4: K802- Calculus of gallbladder without cholecystitis

Recruitment & Eligibility

Inclusion Criteria

1. Any age ranges from 18 to 60 years old.

2. Both sex included with Low Anesthetic Risk Score of 1 or 2 according to the American Society of Anesthesiologists (ASA).

3. Mild to moderate cholecystitis and simple symptomatic gallbladder stone disease, as confirmed by USG.

Exclusion Criteria

1. Gall bladder malignancy.

2. Acute cholecystitis.

3. Choledocholithiasis.

4. H/O ERCP with and without a stent in place.

5. Other causes of shoulder pain such subacromial bursitis, rheumatoid arthritis, tendinitis, and other musculoskeletal conditions;

coronary artery diseases; COPD; asthma; history of cancer; jaundice; or any other co-morbidity.

6. Who had previous upper abdomen surgery.

7. BMIs below 18.5 or above 29.9.

8. ASA grades III, IV, or ,V.

9. Cognitive impairment, long-term painkiller use, or a history of alcohol addiction.

10. People who have been found with acute cholecystitis by ultrasonography or who have had it in the past.

Primary Outcome Measures

Name	Time	Method
1. To determine if there is a significant difference in pain levels, as measured by the Visual Analogue Score (VAS), at four pre determined time points: 6hours, 12 hours, 24 hours, and 7 days post-operation among patients undergoing laparoscopic cholecystectomy with low- <br/ ><br>pressure pneumoperitoneum compared to standard pressure. <br/ ><br>2.To evaluate significant changes in inflammatory markers from baseline values in the same patient population.Timepoint: 6hours, 12 hours, 24 hours, and 7 days Post-Laparoscopic Cholecystectomy

Secondary Outcome Measures

Name	Time	Method
To assess and compare theneed for additional pain medicationpost-operationbetween the low-pressure and standard-pressure pneumoperitoneum groups. <br/ ><br>To record and compare the length of time the surgery takes under low-pressure versus standard-pressure pneumoperitoneum. <br/ ><br>To evaluate and compare the level of difficulty experienced by the surgeon during the procedure in both groups <br/ ><br>To note and compare the necessity of placing adrain during or after the surgery in both patient groups. <br/ ><br>To monitor and compare the length ofthe hospital stay post-surgery between thetwo groups.Timepoint: intra op ,6hr,12hr,24hr and 7 days