Peri-operative Magnesium infusion to Prevent Atrial fibrillation Evaluated.

Recruiting

Conditions: atrial fibrillation
cardiac arrhythmia
10007521

Registration Number: NL-OMON54180

Lead Sponsor: HagaZiekenhuis

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 530

Inclusion Criteria

- Elective cardiac surgery (valve surgery and/or CABG)
- 18 years and above

Exclusion Criteria

- History of atrial fibrillation (AF) or atrial flutter
- Concomitant rhythm associated procedures (MAZE (surgical ablation)/PVI
(pulmonary vein isolation))
- Pre-existing severe renal impairment (eGFR<30 ml/min) or development of
oliguria post-surgery (<200 ml in previous 6 hours) and/or rise in creatinine
with eGFR <30 ml/min)
- Significant hypotension persisting for 1 hour or longer (Noradrenaline >0.1
mcg/kg/min)
- Development of third-degree heart block during index admission or
pre-existing 3rd degree heart block without pacemaker presence.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Measurement of the incidence patients with POAF in the first 7 days<br /><br>post-surgery has been defined as primary endpoint. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary endpoints include duration of POAF, peak heart rate during POAF,<br /><br>Length of Hospital stay (LOHS) and ICU Length Of Stay (LOS), duration of<br /><br>mechanical ventilation, inotropic and/or vasopressor support, combined outcome<br /><br>of 28-day mortality, stroke, pulmonary embolism, delirium (requiring<br /><br>anti-psychotic medication), infection requiring antibiotics and POAF. </p><br>