Repetitive Transcranial Magnetic Stimulation in the treatment of Huntington’s Chorea
Not Applicable
- Conditions
- Huntington's diseaseHuman Genetics and Inherited Disorders - Other human genetics and inherited disordersNeurological - Neurodegenerative diseases
- Registration Number
- ACTRN12612001173886
- Lead Sponsor
- orth Metropolitan Area Health Service
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Patients who attended that Huntington’s Study Group (HSG) at the Neurosciences Unit, Graylands Hospital, who have choreic movements, and for whom the movements are especially intrusive or poorly controlled, will be offered the option of the rTMS trial.
Exclusion Criteria
Children.
Pregnancy.
History of epilepsy.
Metal implants in the head.
Pacemaker
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Reduction in choreic movements. The UHDRS chorea severity scale.[Before and after each rTMS session.];Global Huntington's severity. General measures for each patient will be made with the Unified Huntington's Disease Rating Scale (UHDRS).[Baseline and Final (after 2 week periods)]
- Secondary Outcome Measures
Name Time Method Cortical excitability will be measured using a varying number of standard techniques depending on the patient's comfort. <br>The motor evoked potentials (MEP) threshold curves using MEP amplitude at the Abductor Pollicus Brevis muscle, short-interval cortical inhibition (SICI), long-interval cortical inhibition (LICI), interacortical facilitation and inhibition (IFI), intercortical facilitation and inhibition (IHI, IHF), and silent period have all been used as measures of excitability, but impose varying demands on the patient.[Before and after each rTMS session.]