Hemodynamic Phenotype-Based, Capillary Refill Time-Targeted Resuscitation In Early Septic Shock: The ANDROMEDA-SHOCK-2 Randomized Clinical Trial (A2) - ANDROMEDA-SHOCK-2

Pontificia Universidad Católica de Chile0 个研究点目标入组 500 人开始时间: 2022年2月10日最近更新: 2022年5月16日

适应症

试验速览

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•- Consecutive adult patients (= 18 years) with septic shock according to Sepsis-3 consensus conference. In short, septic shock is defined as suspected or confirmed infection, plus hyperlactatemia and NE requirements due to persistent hypotension, after a fluid load of at least 1000mL in 1h.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 400
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 100

•- More than 4 hours since septic shock diagnosis
•- Anticipated surgery or acute hemodialysis procedure to start during the 6h intervention period
•- Active bleeding
•- Do not resuscitate status
•- Child B-C Cirrhosis
•- Underlying disease process with a life expectancy < 90 days and/or the attending clinician deems aggressive resuscitation unsuitable
•- Refractory shock (high risk of death within 24h)
•- Pregnancy
•- Concomitant severe acute respiratory distress syndrome.
•- Patients in whom CRT cannot be accurately assessed

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