A Pilot Study of the Acute Effect of Essential Oils from Zingiber montanum on Mood, Stress, Learning, and Memory in Thai Male Healthy Volunteers
Phase 2
Recruiting
- Conditions
- Healthy Male volunteers,age 18ᆭ years old,graduated from high school (grade 12)
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Male
- Target Recruitment
- 40
Inclusion Criteria
1. Healthy Male volunteers, age 18-25 years old
2. graduated from high school (grade 12)
3. Willing to participate in the study
Exclusion Criteria
1. Brain diseases, previous head injury
2. Nasal obstruction, active rhinorrhea/ rhinitis, sinusitis
3. Anosmia or hyposmia
4. use CNS suppressants such assedatives-hypnotics, anti-depressants, antipsychotics, opioid analgesics, first-generation antihistamines, or alcohol consumption 2 weeks prior enrollment
5. use CNS stimulants such as pseudoephredrine, amphetamines and its derivatives, nicotine, caffeine, methylxanthines
6. Previous brain surgery
7. Hypersensitivity to olive oil or Zingiber montanum
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cognitive function pre-inhalation and post-inhalation Montreal Cognitive Assessment (MoCA) ,Mood scales pre-inhalation and post-inhalation VAS for mood/ anxiety/ stress/ alertness,Attention and working memory pre-inhalation and post-inhalation Digit Span forward / backward (Wechsler memory scale),Memory via Verbal fluency test, Word list learning test pre-inhalation and post-inhalation Controlled oral word association test (Halstead-Reitan Neuropsychological battery), word recall test
- Secondary Outcome Measures
Name Time Method Psychodynamic formulation pre-inhalation and post-inhalation Rorchach (Inkblot) Test