Is The Occurrence of IgA-Nephropathy modulated by Gene Mutations of Phase 1 and 2 Detoxification Enzymes?
Recruiting
- Conditions
- CKD with particular reference to IgA nephropathy
- Registration Number
- DRKS00012928
- Lead Sponsor
- Förderverein Nephrologie e.V.
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 200
Inclusion Criteria
Histologic proven IgA nephropathy in Caucasians of either sex
For the controls: chronic kidney disease patients without glomerulonephritis in Caucasians of either sex
Further controls: published SNP- frequencies of phase I and II gene (rate of polymorphisms in the general population)
Exclusion Criteria
none
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Prevalences of genetic variants in enzymes of phase I and II will be assessed in patients with histologic proven IgA nephropathy. Genetic variants will be analysed by means of DNA from EDTA blood samples and set in comparison to the prevalence in chronic kidney disease patients without glomerulonephritis as well as to the published SNP (single nucleotide polymorphism) frequencies of data bases.
- Secondary Outcome Measures
Name Time Method Progression of the disease based on GFR in relation to the number of genetic variants