Mikrobiologi Ved svær Akut Tonsillit, peritonsillær Phlegmone og infektiøs Mononukleose
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 350
- 试验地点
- 1
- 主要终点
- Prevalence of Fusobacterium necrophorum in throat swab cultures
研究概览
简要总结
Prospective, observational study of the microbiology of patients referred to a tertiary care center with severe acute tonsillitis, peritonsillar cellulitis, or infectious mononucleosis.
详细描述
Patients referred to tertiary care centers with acute throat infections are most often treated with antibiotics. However, very little is know concerning the prevalent pathogens in patients with acute throat infections without abscess formation. Evidence suggests that Fusobacterium necrophorum plays an important role in complications of acute tonsillitis (e.g. peritonsillar abscess), but also uncomplicated acute tonsillitis.
This study aims to explore the throat microbiology of patients with severe acute tonsillitis, peritonsillar cellulitis, or infectious mononucleosis with a special attention to a possible role of Fusobacterium necrophorum.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 15 Years 至 40 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients referred to our tertiary care center with acute tonsillitis with or without signs of peritonsillar cellulitis and with or without infectious mononucleosis.
- •Center Score 3 or 4.
排除标准
- •Abscess formation.
- •Previous tonsillectomy.
结局指标
主要结局
Prevalence of Fusobacterium necrophorum in throat swab cultures
时间窗: At acute consultation (day 0)
次要结局
- Number of participants with complications of severe acute tonsillitis, peritonsillar cellulitis, and infectious mononucleosis(14-28 days after acute consultation)
- Number of participants with recurrent throat infections (questionnaire)(Six months after acute consultation)
- Number of participants without eradication of throat pathogens (throat cultures)(14-28 days after acute consultation)
- Prevalence of anti-Fusobacterium necrophorum antibody Development (two-fold or higher increase in antibody level) (blood samples)(In acute and convalescent sera (day 0 and 14-28))
研究者
Tejs Ehlers Klug
Consultant, associate professor
Aarhus University Hospital