Mikrobiologi Ved svær Akut Tonsillit, peritonsillær Phlegmone og infektiøs Mononukleose
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Enrollment
- 350
- Locations
- 1
- Primary Endpoint
- Prevalence of Fusobacterium necrophorum in throat swab cultures
Study Overview
Brief Summary
Prospective, observational study of the microbiology of patients referred to a tertiary care center with severe acute tonsillitis, peritonsillar cellulitis, or infectious mononucleosis.
Detailed Description
Patients referred to tertiary care centers with acute throat infections are most often treated with antibiotics. However, very little is know concerning the prevalent pathogens in patients with acute throat infections without abscess formation. Evidence suggests that Fusobacterium necrophorum plays an important role in complications of acute tonsillitis (e.g. peritonsillar abscess), but also uncomplicated acute tonsillitis.
This study aims to explore the throat microbiology of patients with severe acute tonsillitis, peritonsillar cellulitis, or infectious mononucleosis with a special attention to a possible role of Fusobacterium necrophorum.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 15 Years to 40 Years (Child, Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Patients referred to our tertiary care center with acute tonsillitis with or without signs of peritonsillar cellulitis and with or without infectious mononucleosis.
- •Center Score 3 or 4.
Exclusion Criteria
- •Abscess formation.
- •Previous tonsillectomy.
Outcomes
Primary Outcomes
Prevalence of Fusobacterium necrophorum in throat swab cultures
Time Frame: At acute consultation (day 0)
Secondary Outcomes
- Number of participants with complications of severe acute tonsillitis, peritonsillar cellulitis, and infectious mononucleosis(14-28 days after acute consultation)
- Number of participants with recurrent throat infections (questionnaire)(Six months after acute consultation)
- Number of participants without eradication of throat pathogens (throat cultures)(14-28 days after acute consultation)
- Prevalence of anti-Fusobacterium necrophorum antibody Development (two-fold or higher increase in antibody level) (blood samples)(In acute and convalescent sera (day 0 and 14-28))
Investigators
Tejs Ehlers Klug
Consultant, associate professor
Aarhus University Hospital