Transcranial Direct Current Stimulation for Post-Stroke Aphasia

Not Applicable

Terminated

• Conditions: Stroke
• Interventions: Behavioral: Aphasia therapy; Device: Anodal tDCS; Device: Sham tDCS

• Registration Number: NCT02461355
• Lead Sponsor: Columbia University

Brief Summary

This is a randomized, crossover design trial that will compare how anodal transcranial direct current stimulation (tDCS) versus sham tDCS administered during multiple sessions of scripting therapy affects the acquisition and retention of trained scripts.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2015-04-08
• Study Start: 2015-06
• Study First Submitted QC: 2015-06-02
• Study First Posted: 2015-06-03
• Primary Completion: 2016-06
• Study Completion: 2016-06
• Results First Submitted: 2019-03-26
• Status Verified: 2019-04
• Results First Submitted QC: 2019-04-17
• Last Update Submitted: 2019-04-17
• Results First Posted: 2019-05-09
• Last Update Posted: 2019-05-09

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 2

Inclusion Criteria

1. Age over 21 years
2. Ischemic left hemispheric stroke verified by imaging (CT or MRI) greater than 6 months ago
3. Residual non-fluent or anomic aphasia, with Western Aphasia Battery-Revised Aphasia Quotient score <60
4. Fluent English speaker prior to stroke
5. Right-handed prior to stroke
6. Ability to give informed consent and understand the tasks involved.

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Exclusion Criteria

1. History of recurrent stroke, either ischemic or hemorrhagic, in the left middle cerebral artery territory
2. Imaging unavailable
3. Large middle cerebral artery infarct involving entire inferior division (temporo-parietal) territory
4. History of dementia prior to the stroke
5. History of seizure, prior electroconvulsive therapy, deep brain stimulators, or brain surgery
6. Social and/or personal circumstances that interfere with ability to return for therapy and assessment sessions.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Anodal tDCS	Anodal tDCS	Anodal tDCS over the left posterior language areas during aphasia therapy for 8 one-hour sessions
Anodal tDCS	Aphasia therapy	Anodal tDCS over the left posterior language areas during aphasia therapy for 8 one-hour sessions
Sham tDCS	Sham tDCS	Sham tDCS over the left posterior language areas during aphasia therapy for 8 one-hour sessions
Sham tDCS	Aphasia therapy	Sham tDCS over the left posterior language areas during aphasia therapy for 8 one-hour sessions

Primary Outcome Measures

Name	Time	Method
Change in Words Per Minute of Trained Scripts	From Baseline to up to 2 days post-training
Change in Percent Correct of Trained Scripts	From Baseline to up to 2 days post-training

Secondary Outcome Measures

Name	Time	Method
Change in Words Per Minute of Trained Scripts	Baseline to 2 weeks and 4 weeks post-training
Change in Percent Correct of Trained Scripts	Baseline to 2 weeks and 4 weeks post-training

Trial Locations

Locations (1)

Adler Aphasia Center; 🇺🇸 Maywood, New Jersey, United States