Enhancing Aphasia Therapy With Anodal Transcranial Direct Current Stimulation in Chronic Stroke Patients
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 2
- 试验地点
- 2
- 主要终点
- Change in Words Per Minute of Trained Scripts
研究概览
简要总结
This is a randomized, crossover design trial that will compare how anodal transcranial direct current stimulation (tDCS) versus sham tDCS administered during multiple sessions of scripting therapy affects the acquisition and retention of trained scripts.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 21 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age over 21 years
- •Ischemic left hemispheric stroke verified by imaging (CT or MRI) greater than 6 months ago
- •Residual non-fluent or anomic aphasia, with Western Aphasia Battery-Revised Aphasia Quotient score <60
- •Fluent English speaker prior to stroke
- •Right-handed prior to stroke
- •Ability to give informed consent and understand the tasks involved.
排除标准
- •History of recurrent stroke, either ischemic or hemorrhagic, in the left middle cerebral artery territory
- •Imaging unavailable
- •Large middle cerebral artery infarct involving entire inferior division (temporo-parietal) territory
- •History of dementia prior to the stroke
- •History of seizure, prior electroconvulsive therapy, deep brain stimulators, or brain surgery
- •Social and/or personal circumstances that interfere with ability to return for therapy and assessment sessions.
研究组 & 干预措施
Anodal tDCS
Anodal tDCS over the left posterior language areas during aphasia therapy for 8 one-hour sessions
干预措施: Aphasia therapy (Behavioral)
Anodal tDCS
Anodal tDCS over the left posterior language areas during aphasia therapy for 8 one-hour sessions
干预措施: Anodal tDCS (Device)
Sham tDCS
Sham tDCS over the left posterior language areas during aphasia therapy for 8 one-hour sessions
干预措施: Aphasia therapy (Behavioral)
Sham tDCS
Sham tDCS over the left posterior language areas during aphasia therapy for 8 one-hour sessions
干预措施: Sham tDCS (Device)
结局指标
主要结局
Change in Words Per Minute of Trained Scripts
时间窗: From Baseline to up to 2 days post-training
Change in Percent Correct of Trained Scripts
时间窗: From Baseline to up to 2 days post-training
次要结局
- Change in Words Per Minute of Trained Scripts(Baseline to 2 weeks and 4 weeks post-training)
- Change in Percent Correct of Trained Scripts(Baseline to 2 weeks and 4 weeks post-training)