Profiling skeletal muscle loss during leg immobilisatio

Not Applicable

Completed

• Conditions: Skeletal muscle atrophy; Musculoskeletal - Other muscular and skeletal disorders

• Registration Number: ACTRN12616001399482
• Lead Sponsor: Bond University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-10-10
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 40

Inclusion Criteria

Physically active individuals undertaking 5 h per week of moderate-vigorous exercise

Exclusion Criteria

Recent (<6 months) injury requiring immobilsation, medical conditions that would place participants at increased risk during
exercise, currently taking medications known to affect body composition, employment requiring physical labour.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in quadriceps muscle mass quantified by MRI and DEXA scans[Baseline (Day 0), day 3 and day 14 measurements];Exploratory genetic analysis using RNA sequencing will be undertaken to better understand RNA expression changes in blood and muscle tissue samples due to immobilization induced atrophy.[Day 0 and day 14]

Secondary Outcome Measures

Name	Time	Method
Change in muscle strength as determined by isometric and isoinertial testing[Baseline (day 0) and day 14]