Evaluation of the effectiveness of a rapid test and treatments for Chagas disease: Oxente Chagas Bahia Cohort

Centro de Pesquisas Gonçalo Moniz0 sitesAugust 15, 2024

Overview

No summary available.

Registry

who.int

Start Date

August 15, 2024

End Date

December 20, 2027

Last Updated

last year

Study Type

Observational

Sponsor

Centro de Pesquisas Gonçalo Moniz

•Part A: Volunteers residing in the municipalities of Tremedal and Novo Horizonte, Bahia, with active registration in municipal health systems; both genders; and aged over nine months. Part B: Volunteers who tested positive with the Bio\-Manguinhos Rapid Chagas Test, along with 10% of those who tested negative; both genders; and aged over nine months. Part C: Volunteers with laboratory\-confirmed Chagas disease; both genders; aged under fifty years; and with a normal electrocardiogram (heart rate: 50\-100 beats per minute, waves P and R (PR) interval \= 200 milliseconds, waves Q, R, and S (QRS) complex \= 120 milliseconds, and waves Q and T (QT) interval between 350\-450 milliseconds)

•Parts A and B: Volunteers residing in Novo Horizonte or Tremedal, Bahia, who are not registered with the local health systems will be excluded from the study, as will volunteers unable to undergo peripheral blood collection. Part C: Exclusion criteria include volunteers with signs of advanced chronic Chagas disease; diagnosis of HIV/AIDS, mental illness, or suicidal tendencies; any acute or chronic disease deemed contraindicated for treatment by the attending physician; history of alcoholism or drug use; known hypersensitivity to nitroimidazoles; and unavailability to comply with the procedures and visits outlined in the protocol