Early high-dose vitamin C in post-cardiac arrest syndrome.

Phase 2

Recruiting

• Conditions: na reanimatie; organ dysfunction after cardiopulmonary resusciation; Post cardiac arrest syndrome; 10011082

• Registration Number: NL-OMON55399
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 360

Inclusion Criteria

Patients admitted to the Intensive Care after out-of-hospital cardiac arrest
with return of spontaneous circulation, ventricular fibrillation or ventricular
tachycardia as first registered cardiac rhythm and EMV-score <=8.

Exclusion Criteria

Patients with pre-existent terminal renal insufficiency (i.e. receiving renal
replacement therapy (RRT)), known glucose 6-phosphate dehydrogenase deficiency
(risk of hemolysis), history of urolithiasis, oxalate nephropathy,
hemochromatosis or treatment limitations will be excluded.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>We will determine organ failure at 96 hours measured by the delta (&Delta;)<br /><br>Sequential Organ Failure Assessment (SOFA) score. &Delta;SOFA score is defined as the<br /><br>difference between SOFA admission and SOFA at 96 hour. Death at 96-hours will<br /><br>be counted as the maximum SOFA score (24 points). </p><br>