Impact of Genetic Testing on Low-density Lipoprotein Cholesterol in Patients with Familial Hypercholesterolemia

Not Applicable

• Conditions: Familial hypercholesterolemia

• Registration Number: JPRN-UMIN000029375
• Lead Sponsor: Kanazawa University Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-10-02
• Study Completion: 2020-03-31
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Not provided

Exclusion Criteria

1) Liver dysfunction (AST or ALT > 3 times the UNL) 2) Renal dysfunction (Cr 2.0 mg/dL or greater) 3) Immunosuppression 4) Active cancer 5) Previous history of coronary heart disease: i) Myocardial infarction ii) History of percutaneous coronary intervention iii) Coronary stenosis (75% or greater) previously detected by coronary angiography 6) Female with pregnancy or expected 7) Patients whose doctors in charge consider him/her inappropriate to participate

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
DL cholesterol levels at 24 weeks after randomization.

Secondary Outcome Measures

Name	Time	Method
Blood test results (total cholesterol, triglyceride, HDL-C, LDL-C, FBG, HbA1C, WBC, RBC, Hemoglobin, Hematocrit, Platelet, ALT, AST, gamma GTP, ALP, T-Bil. Cr, BUN. TP, Alb, UA, Na, K, Cl, Ca, P, hsCRP), smoking habit, drug adherence, and patient satisfaction questionnaire (PSQ-18) score at 24 and 48 weeks after randomization between intervention/control and/or genetic test positive / negative groups.