An Iodine Balance Study in the Elderly
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Enrollment
- 30
- Locations
- 3
- Primary Endpoint
- Iodine excretion
Study Overview
Brief Summary
Current Chinese dietary iodine reference intake (DRIs) standards lack direct data on recommended iodine intake (RNI) in the elderly. The elderly have a high prevalence of thyroid diseases. The risk threshold of iodine intake in the elderly is unknown. Identifying the appropriate iodine intake for the elderly to maintain optimal thyroid function to reduce the burden on medical resources is a public health issue requiring high attention. The iodine balance study is an important method for exploring physiological iodine requirements. Few iodine balance studies have been conducted in the elderly. This study aimed to conduct an iodine balance study and provide information on the appropriate iodine intake level for elderly people.
Detailed Description
The investigators measured subjects' food and water intake throughout the day using weighing methods, and collected all urine and fecal samples. Food, drinking water, fecal and urine samples were taken to determine iodine concentrations. Each subject was required to participate in two phases of iodine balance studies. Each stage lasts 4 to 10 days. There was no intervention in the first half of the experiment, and there was an intervention of iodized salt/non-iodized salt consumption in the second half of the experiment. The appropriate level of iodine intake for the elderly was explored by fitting and analyzing the dose change relationship between iodine intake and iodine excretion.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Sequential
- Primary Purpose
- Health Services Research
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •The target population of this study is elderly people over 60 years old. Adults living in the same household can also participate.
- •Inclusion Criteria:
- •aged 18 and above;
- •at least 5 years of local residence.
Exclusion Criteria
- •family genetic diseases；
- •special dietary habits；
- •taking iodine-containing drugs or supplements；
- •metabolic diseases;
- •thyroid diseases.
Outcomes
Primary Outcomes
Iodine excretion
Time Frame: Each phase of the iodine balance study lasts 4 to 10 days.
Daily iodine excretion includes urinary iodine excretion and fecal iodine excretion.
Iodine intake
Time Frame: Each phase of the iodine balance study lasts 4 to 10 days.
Daily iodine intake includes dietary iodine intake and drinking water iodine intake.
Secondary Outcomes
- thyroid function indexes(Within one week before the start of the experiment.)
- salivary iodine(4 to 10 days)
- blood pressure(Within one week before the start of the experiment.)
- thyroid volumn(Within one week before the start of the experiment.)
- fasting blood glucose(Within one week before the start of the experiment.)
Investigators
Wenxing Guo
School of Public Health
Tianjin Medical University