Evaluation of dermatological safety of investigational products by primary irritation patch test on healthy human volunteers of varied skin types.

**Objective:**The objective of this study is to evaluate the dermatological safety of the given investigational product/s on skin of healthy human volunteers.

Product/s will be evaluated by carrying out patch test under occlusion for 24 hours.

.  Subject Population:

 24 healthy human volunteers (Male and Female 1:1)

Skin types (Oily, Dry, Normal and Combination, 1:1:1:1 ratio).

Duration of study:

5 visits (9 days for each volunteers)

7.  Inclusion / Exclusion Criteria:

7.1 Inclusion Criteria:

�         Subjects age group 18 - 55 years

�         Healthy male & female volunteers

�         Subjects with skin type III to V.

�         Subjects willing to give a written informed consent.

�         Subjects willing to maintain the patch test in position for  24 hours

�         Subject has not participated in a similar investigation in the past two weeks.

�         Subjects willing to come for regular follow up.

�         Subjects ready to follow instructions during the study period.

 7.2  Exclusion Criteria:

�         Infection, allergy on the tested area

�         Skin allergy antecedents or atopic subjects

�         Hyper sensitivity to any component of the tested products

�         Athletes and subjects with history of excessive sweating

�         Cutaneous disease which may influence the study result

�         Chronic illness which may influence the cutaneous state.

�         Subjects on oral corticosteroid with dose >10mg/day

�         Subjects participating in any other cosmetic or therapeutic trial.

�         Any history of underlying uncontrolled medical illness including diabetes, liver disease or history of alcoholism, HIV or any other serious medical illness.