The Role of Genetic Factors in the Development of Idiopathic Scoliosis in the Kazakh Population

Completed

• Conditions: Idiopathic Scoliosis
• Interventions: Genetic: SNP analysis of the DNA

• Registration Number: NCT05095129
• Lead Sponsor: Asfendiyarov Kazakh National Medical University

Brief Summary

The purpose of this study is to identify genetic determinants of susceptibility to idiopathic scoliosis . It will assist in predicting individual risks of disease progression and would help to clarify pathophysiologic mechanisms of idiopathic scoliosis

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-10-21
• Study First Submitted QC: 2021-10-26
• Study First Posted: 2021-10-27
• Study Start: 2022-03-23
• Primary Completion: 2023-01-20
• Study Completion: 2023-01-20
• Status Verified: 2023-03
• Last Update Submitted: 2023-03-13
• Last Update Posted: 2023-03-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

1. Persons with a doctor-confirmed diagnosis of idiopathic scoliosis;
2. Persons of Kazakh nationality, whose paternal and maternal grandparents are Kazakhs;
3. Hereditary history of scoliosis;
4. Persons who are able and willing to provide written informed consent;

Exclusion Criteria

1. Patients diagnosed with idiopathic scoliosis under 4 and over 40 years of age;
2. Representatives of the Kazakh ethnic group less than 3 generations;
3. No family history of bilateral idiopathic scoliosis;
4. Patients with an acute period of the inflammatory process (laboratory and clinical signs);
5. Persons who, in the opinion of the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent;
6. Pregnant or lactating women;
7. Tuberculosis of any localization in the active phase and in history;
8. Severe and decompensated diseases of the liver and kidneys, cardiovascular system;
9. Severe and decompensated course of endocrine diseases;
10. Autoimmune diseases;
11. Systemic diseases;
12. Oncological diseases;

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Experimental group:	SNP analysis of the DNA	patients with idiopathic scoliosis
Control group	SNP analysis of the DNA	patients without idiopathic scoliosis

Primary Outcome Measures

Name	Time	Method
Genotyping for the SNP associated with liver cirrhosis	1 year	Genotype frequency of SNP in the study genes of participants and control participants.

Trial Locations

Locations (1)

Scientific center of traumatology and orthopedics named after academician Batpenova ND; 🇰🇿 Almaty, Kazakhstan