Feasibility of Regional Lung Ventilation using X-Ray Velocimetry (XV) in Adult Patients with Chronic Respiratory Conditions.

Not Applicable

• Conditions: Chronic Obstructive Pulmonary Disease (COPD); Asthma; Cystic Fibrosis (CF); Idiopathic Pulmonary Fibrosis (IPF); Primary ciliary dyskinesia (PCD); Respiratory - Chronic obstructive pulmonary disease; Respiratory - Asthma; Respiratory - Other respiratory disorders / diseases; Human Genetics and Inherited Disorders - Cystic fibrosis

• Registration Number: ACTRN12623000889651
• Lead Sponsor: niversity of New South Wales

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-08-21
• Last Update Posted: 9 September 2024

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1. Has a known history of a chronic respiratory condition (such as COPD, asthma, CF, IPF or PCD) that is clinically stable, as defined by no change in medications or hospitalisations, over the preceding four-week period, prior to study recruitment.
2. Male or female adults, 18 years of age and older.
3. Is known to require a chest CT or has a historical chest CT that is representative of the patient’s present lung anatomy (i.e. ideally undertaken within 12-24 months of recruitment to the study).

Exclusion Criteria

1. Currently receiving mechanical ventilation, intensive or other critical care.
2. Pregnant women, confirmed by a positive pregnancy test.
3. Women of child-bearing potential who are unable or unwilling to undergo urine pregnancy test(s) to exclude pregnancy at study visit(s).
4. Contraindication to ionising radiation.
5. Patient weight >150kg (limited by XV scanner’s tolerance).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess the feasibility of the XV scanner for the assessment of lung function in patients with chronic respiratory conditions.<br>Feasibility will be determined comparing XV scan outputs to pulmonary function test measures (spirometric values, MBW, DLCO and lung volumes). [ Primary evaluation will be done at Visit 1A (main study visit). <br><br>]