Evaluating the Real-World Performance of Artificial Intelligence (AI)-Based Detection for Interstitial Lung Disease in Chest X-Ray Images
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,293
- 试验地点
- 1
- 主要终点
- Positive predictive value (PPV) of AI-detected interstitial opacity
研究概览
简要总结
The goal of this observational study is to learn how well an artificial intelligence (AI)-based chest X-ray analysis software can incidentally detect interstitial lung disease (ILD), which appears as interstitial opacity, on chest X-rays taken for other reasons, and whether these AI-flagged findings represent true interstitial opacity.
The main question it aims to answer is: How often does an AI-flagged interstitial opacity correspond to true ILD?
This retrospective study uses existing records: researchers review each participant's follow-up computed tomography(CT), CT report, and final diagnosis to confirm true ILD and reticular opacity.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adults aged 19 years or older
- •Visited the pulmonology and allergy clinic (outpatient or inpatient) at Chung-Ang University Hospital (Seoul or Gwangmyeong) and underwent chest radiography from January 2022 to December 2024
- •A follow-up CT performed after the index chest radiograph
- •Reticular/interstitial opacity detected on the index radiograph by VUNO Med®-Chest X-ray™
排除标准
- •Prior history of ILD or ILD-related disease before the index chest radiograph, or a CT report containing terms related to interstitial opacity
- •Non-frontal (non-posteroanterior/anteroposterior [PA/AP]) chest radiograph view position
- •Missing CT report or final clinical diagnosis
结局指标
主要结局
Positive predictive value (PPV) of AI-detected interstitial opacity
时间窗: From the index chest radiograph to the reference standard confirmation (the first follow-up CT after the index chest radiograph and/or final clinical diagnosis), up to 3.5 years
Positive predictive value (PPV) of the AI flag for interstitial opacity is the proportion of AI interstitial-opacity-positive index radiographs confirmed as true positives by the radiologist reference standard (consensus review of the paired follow-up CT, CT report, follow-up diagnoses, and the index radiograph). PPV = true positives / all AI interstitial-opacity-positive cases.
次要结局
- Comparison of AI finding scores between true-positive and false-positive cases(From the index chest radiograph to the reference standard confirmation (the first follow-up CT after the index chest radiograph and/or final clinical diagnosis), up to 3.5 years)
研究者
Kyoungmin Moon
Associate Professor of Pulmonary and Allergy Medicine
Chung-Ang University Hospital