Gammaglobulins Level is Predictive Factor of Evolution in Sarcoidosis

Completed

• Conditions: Sarcoidosis

• Registration Number: NCT03259282
• Lead Sponsor: Rennes University Hospital

Brief Summary

Evaluation of the rate of achievement of serum protein electrophoresis (PPE) in diagnosis in a retrospective cohort of patients at Rennes University Hospital

Detailed Description

In 50% of cases, sarcoidosis is associated with polyclonal hypergammaglobulinemia. The other forms have a normal gamma globulin level.

The level of gamma globulinemia has not yet been studied as an evolutionary predictive factor. Furthermore, there are disseminated granulomatoses sharing common characteristics with sarcoidosis, associated with Common Variable Immunodeficiency deficit (DICV) type Primary Immunodeficiency syndrome (DIP), thus occurring in hypogammaglobulinemic patients.

Study Timeline

• Study Start: 2017-03-07
• Primary Completion: 2017-03-22
• Study Completion: 2017-03-22
• Study First Submitted: 2017-08-21
• Study First Submitted QC: 2017-08-21
• Study First Posted: 2017-08-23
• Status Verified: 2018-04
• Last Update Submitted: 2018-04-10
• Last Update Posted: 2018-04-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 78

Inclusion Criteria

• Patients newly diagnosed with sarcoidosis

Exclusion Criteria

• Comorbidity responsible for a change in the level of gamma globulin
• Other etiology of granulomatosis

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Study of gamma globulin level present in the blood at the time of diagnosis of sarcoidosis on disease activity	Day 1	Electrophoresis rates of serum proteins
Study of gamma globulin level present in the blood at the time of diagnosis of sarcoidosis on the course of the disease	Day 1	Electrophoresis rates of serum proteins

Trial Locations

Locations (1)

CHU de Rennes; 🇫🇷 Rennes, France