Apatinib Plus Etoposide Versus Etoposide Alone for Platinum-resistant Recurrent Ovarian Cancer: A Randomized Controlled Trial
试验速览
- 阶段
- 2 期
- 发起方
- 入组人数
- 60
- 主要终点
- Disease Control Rate
研究概览
简要总结
It is a prospective multi-center trial, platinum-resistant ovarian cancer patients will be randomized in two groups, one group will be treated with Apatinib plus Etoposide, the other will be treated with Etoposide alone. It is aimed to see the efficacy and safety of Apatinib plus Etoposide for the platinum-resistant ovarian cancer patients
详细描述
It is a randomized controlled trial, the aim is to see the efficacy and safety of Apatinib plus Etoposide treating platinum-resistant ovarian cancer. The main primary end point is DCR (disease control rate), the secondary endpoint is Duration of response（DOR），overall survival (OS), time to progression (TTP)，quality of life (QoL, according to EORTC QLQ-C30).The key safety indicators include the patients' vital signs, laboratory indicators, adverse events(AE),serious adverse events.
The data collection duration is from the day ICF assigned to the day(30 days after the end of the last medication).From the day ICF signed to the end of the study, all adverse events were recorded in the CRF. The severity of the adverse events will be evaluated according to the NCI CTCAE 4.0 standard.Each patient will receive a planned visit and specific data at different points will be recorded in the visit.
The patients will be followed up after quitting the trial because of disease progression or intolerance. The following parameters were recorded during follow-up: disease recurrence,metastasis,death time,SAE occurred during the study; survival (available with telephone follow-up, record required).
Adverse events that have not been recovered when the drug is discontinued should be tracked and finalized. All patients should undergo a 30-day follow-up after the last medication to find any new adverse events.
All cases should be recorded carefully and completely, the investigator should be responsible for the authenticity of the center's data.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •ECOG PS：0-2 points
- •Platinum-resistant recurrent ovarian cancer patients with measurable recurrent focus
- •The damage caused by other treatment has been restored (NCI-CTCAE 4.0 Graded ≤ 1 level), Other cytotoxic drugs treatment, radiotherapy or surgery≥ 4 week; EGFR TKI treatment ≥ 2 week
- •Baseline routine blood test and biochemical indicators meet the following criteria:
- •Hemoglobin ≥ 90g / L
- •Neutrophil absolute count (ANC) ≥ 1.5 × 109 / L
- •Platelets ≥80 × 109 / L
- •ALT, AST ≤ 2.5 × ULN or 5 × ULN (with liver metastases)
- •Total Serum bilirubin ≤ 1.5 × ULN
- •Serum creatinine≤1.5×ULN or endogenous creatinine clearance ≥ 45ml/min (according to Cockcroft-Gault formula);
- •No blood and blood products transfusion in 14 Days
- •Expected survival time≥3 month;
- •Subjects volunteer to join the study, sign informed consent, cooperate with follow-up.
排除标准
- •"biochemical recurrence " ovarian cancer patients
- •Patients allergy to apatinib, etoposide and / or its excipients
- •Patients with high blood pressure and who can not be reduced to normal range by antihypertensive therapy (systolic blood pressure> 140 mmHg, diastolic blood pressure> 90 mmHg), with grade I coronary heart disease, grade I arrhythmia (including QTc prolongation > 470 ms)
- •According to NYHA standard, grade Ⅲ-Ⅳ heart failure, or cardiac color Doppler ultrasound examination shows left ventricular ejection fraction (LVEF) <50%
- •Urine protein positive patients
- •With a variety of factors that affect oral medication (such as can not swallow, nausea, vomiting, chronic diarrhea and intestinal obstruction, etc.)
- •Patients with definite gastrointestinal bleeding tendencies, including the following: localized ulcer lesions, and fecal occult blood (++); 2 months with black stool, hematemesis history
- •Patients with coagulation dysfunction (INR> 1.5, APTT> 1.5 ULN), bleeding tendency
- •Existing hereditary or acquired bleeding and thrombotic tendencies (such as hemophilia, coagulation disorders, thrombocytopenia, hypersplenism, etc.)
- •Long untreated wound or fracture;major surgery or severe traumatic injury in 4 weeks, fracture or ulcer
- •Accompanied by abdominal fistula, gastrointestinal perforation or abdominal abscess; active hepatitis B virus or hepatitis C patients
- •Active brain metastases, cancer meningitis, spinal cord compression patients, Imaging CT or MRI examination found the brain or pia mater disease,( brain metastases patients who has complete treatment 21 days before and has stable symptoms can be enrolled , but the need for transcranial MRI, CT or intravenous angiography evaluation confirmed as no cerebral hemorrhage symptoms)
- •Imaging (CT or MRI) shows tumor lesions from large vessels ≤ 5 mm, or lesions invade the Local large blood vessels
- •Lactating women
- •Patients with other malignancies in 5 years (except for cured skin basal cell carcinoma and in situ ovarian cancer)
- •Patients with a history of psychiatric abuse and who can not quit or have mental disorders
- •Patients who participated in other drug clinical trials within 4 weeks
- •Patients who received VEGFR inhibitors such as sorafenib and sunitinib treatment
- •Patients who received Etoposide treatment
- •According to the researcher's judgment, there are serious illnesses that endanger the patient's safety or affect the completion of the study
- •Patients that are not suitable for this trial in the investigator's opinions.
研究组 & 干预措施
Apatinib plus Etoposide
Apatinib,500mg,PO.QD, continuous administration Etoposide,100mg, PO.QD，D1-D10, Q3W
干预措施: Apatinib (Drug)
Apatinib plus Etoposide
Apatinib,500mg,PO.QD, continuous administration Etoposide,100mg, PO.QD，D1-D10, Q3W
干预措施: Etoposide (Drug)
Etoposide
Etoposide,100mg, PO.QD，D1-D10, Q3W
干预措施: Etoposide (Drug)
结局指标
主要结局
Disease Control Rate
时间窗: through study completion, an average of 1.5 years
the proportion of patients who had a best response rating of complete response, partial response, or stable disease
次要结局
- Duration of Response(through study completion, an average of 1.5 years)
- Overall Survival(through study completion, an average of 3 years)
- Time to Progression(through study completion, an average of 1.5 years)
研究者
Yang Zhijun
Associate chief physician
Guangxi Medical University