Effect of CoenzymeQ10 Prophylaxis on Neurosensory Disturbances and Altered Sensation Following Orthognathic Surgery: A Triple-Blind Randomized Controlled Trial and Biochemical Assessment
Phase 4
Recruiting
- Conditions
- Patients undergoing orthognathic surgery using BSSO techniqueCoenzymeQ10 Neurosensory disturbances Peripheral nerve injuries Oxidative stress Neuroinflammation
- Registration Number
- TCTR20231115001
- Lead Sponsor
- Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 94
Inclusion Criteria
1.Non-growing patients (below 45 years old)
2.Healthy status (American Society of Anesthesiologist (ASA) Class I )
3.Undergoing orthognathic surgery using BSSO technique
Exclusion Criteria
1.History of allergy to medications used in this study
2.History of maxillofacial trauma
3.History of neurosensory disturbance of mandible area
4.History of any neurodegenerative diseases
5.Currently receiving any kind of herbs and supplements
6.Being unable to attend follow-up appointments
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method CoenzymeQ10 level preoperative, operative day, 1- week after surgery HPLC method,Malondialdehye level preoperative, operative day, 1- week after surgery HPLC method,TNF-alpha preoperative, operative day, 1- week after surgery ELISA method,Incidence of neurosensory disturbances 1-week after surgery Questionnaires
- Secondary Outcome Measures
Name Time Method Objective neurosensory perception preoperative, 1-week, 1-month, 3-month, 6-month Two-point discrimination,Brush stroke directions, Light touch/contact detections and Pin-prick test,Subjective neurosensory perception preoperative, 1-week, 1-month, 3-month, 6-month questionnaires,Facial swelling evaluation immediate post operative, 1-week, 2 -week, 3-week, 1-month Facial anatomical landmark