NCT02149316已完成不适用
Cardioprotective Effects of Remote Ischemic Preconditioning With Postconditioning of the Recipient on Donor Heart in Heart Transplantation Surgery
Chinese Academy of Medical Sciences, Fuwai Hospital2 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2014年2月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- serum cardiac troponin I (cTnI)
研究概览
简要总结
The purpose of this study is to determine whether remote ischemic preconditioning with postconditioning (RIPC+RIPostC) reduces myocardial injury and improves clinical outcomes in heart transplantation surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 14 Years 至 70 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •scheduled for elective orthotopic heart transplantation surgery
排除标准
- •peripheral vascular disease affecting the upper arms
- •mechanical circulatory support before surgery
- •taking the antidiabetic sulphonylurea, glibenclamide
- •cold ischemic time of donor heart > 12 hours
- •repeated heart surgery
结局指标
主要结局
serum cardiac troponin I (cTnI)
时间窗: within 72 hours after aortic declamping
次要结局
- plasma microRNA-133b (miR-133b)(within 72 hours after aortic declamping)
- plasma microRNA-208a (miR-208a)(within 72 hours after aortic declamping)
研究者
Guyan Wang
The Chief of Infection-Control Department
Chinese Academy of Medical Sciences, Fuwai Hospital
研究点 (2)
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