NCT02149316CompletedNot Applicable
Cardioprotective Effects of Remote Ischemic Preconditioning With Postconditioning of the Recipient on Donor Heart in Heart Transplantation Surgery
Chinese Academy of Medical Sciences, Fuwai Hospital2 sites in 1 country60 target enrollmentStarted: February 1, 2014Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 60
- Locations
- 2
- Primary Endpoint
- serum cardiac troponin I (cTnI)
Study Overview
Brief Summary
The purpose of this study is to determine whether remote ischemic preconditioning with postconditioning (RIPC+RIPostC) reduces myocardial injury and improves clinical outcomes in heart transplantation surgery.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Supportive Care
- Masking
- Double (Participant, Care Provider)
Eligibility Criteria
- Ages
- 14 Years to 70 Years (Child, Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •scheduled for elective orthotopic heart transplantation surgery
Exclusion Criteria
- •peripheral vascular disease affecting the upper arms
- •mechanical circulatory support before surgery
- •taking the antidiabetic sulphonylurea, glibenclamide
- •cold ischemic time of donor heart > 12 hours
- •repeated heart surgery
Outcomes
Primary Outcomes
serum cardiac troponin I (cTnI)
Time Frame: within 72 hours after aortic declamping
Secondary Outcomes
- plasma microRNA-133b (miR-133b)(within 72 hours after aortic declamping)
- plasma microRNA-208a (miR-208a)(within 72 hours after aortic declamping)
Investigators
Guyan Wang
The Chief of Infection-Control Department
Chinese Academy of Medical Sciences, Fuwai Hospital
Study Sites (2)
Loading locations...
Similar Trials
Withdrawn
Phase 1
Effect of Remote Ischemic Preconditioning on Cardiac Function After Cardiac SurgeryVentricular ArrythmiasMyocardial InjuryCardiac FunctionAtrial FibrillationNCT00882622Patrick Meybohm
Completed
Not Applicable
Protection of the Heart With Remote Ischemic Preconditioning During Heart Surgery: A Pilot StudyRemote Ischemic PreconditioningMyocardial ProtectionNCT00546390University of Alberta57
Completed
Not Applicable
Remote Ischaemic Postconditioning in the Clinical Setting of NSTEACS and Urgent PCIPost Procedural Myocardial InfarctionNCT03726164University College, London626
Unknown
Phase 3
The Effect of Remote Ischemic Preconditioning (RIPC) on Blood Pressure and Its Vascular Protection EffectBrachial Plexus PressureNCT02414997First Affiliated Hospital, Sun Yat-Sen University120
Completed
Not Applicable
The Effect of Remote Ischemic Preconditioning on Major Organ Function in Patients With Coronary Artery Disease Undergoing Orthopedic SurgeryMyocardial InfarctionAngina PectorisNCT02808936Seoul National University Hospital60