Artificial Intelligence to Assess the Association Between Facial Characteristics and Coronary Artery Diseases
- Conditions
- Coronary Artery Disease
- Interventions
- Other: No intervention
- Registration Number
- NCT03731936
- Lead Sponsor
- China National Center for Cardiovascular Diseases
- Brief Summary
The purposes of this study are 1) to explore the association between facial characteristics and the increased risk of coronary artery diseases; 2) to evaluate the diagnostic efficacy of appearance factors for coronary artery diseases.
- Detailed Description
Several age-related appearance factors were described associated with increased risk of coronary artery diseases (CAD). However, several limitations made these facial risk factors hard to be utilized in clinical practice, including 1) low prevalence in CAD patients, 2) lack of specific definition, 3) poor reproducibility in artificial recognition.
Thus, the investigators designed a multi-center, cross-sectional study to explore the association between facial characteristics and CAD and evaluate the diagnostic efficacy of appearance factors for CAD. The investigators will recruit patients undergoing coronary angiography or coronary computer tomography angiography. Patients' baseline information and facial images will be collected. First, the investigators will explore the facial factors associated with CAD by using artificial intelligence technology to compare facial photographs between patients with CAD and without CAD. Secondary, the investigators will evaluate the dose-response relationship between facial characteristics and CAD. Third, the investigators will establish a CAD risk model based on facial factors, and evaluate the diagnostic effect of the model.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 6864
- Undergoing coronary angiography or coronary computer tomography angiography
- Written informed consent
- Prior percutaneous coronary intervention (PCI)
- Prior coronary artery bypass graft (CABG)
- Screening coronary artery disease before treating other heart diseases
- Without blood biochemistry outcome
- With artificially facial alteration (i.e. cosmetic surgery, facial trauma or make-up)
- Other situations which make patients fail to be photographed
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Model establishment and test group No intervention Patients undergoing coronary angiography or coronary computer tomography angiography will be enrolled. Patients data will be used to establish the facial based diagnostic model of coronary artery diseases, and to prospectively validate the diagnostic effectiveness of the model.
- Primary Outcome Measures
Name Time Method Sensitivity of diagnostic model at the end of enrollment (6 months) The sensitivity of coronary artery diagnostic model assessed in model test group
- Secondary Outcome Measures
Name Time Method Diagnostic accuracy rate at the end of enrollment (6 months) Diagnostic accuracy rate of diagnostic model assessed in model test group
Specificity of diagnostic model at the end of enrollment (6 months) Area under receiver operating curve (AUC) of diagnostic model assessed in model test group
Positive predictive value (PPV) at the end of enrollment (6 months) PPV of diagnostic model assessed in model test group
Negative predictive value (NPV) at the end of enrollment (6 months) NPV of diagnostic model assessed in model test group
Trial Locations
- Locations (9)
Beijing Anzhen hospital
🇨🇳Beijing, Beijing, China
Fuwai hospital
🇨🇳Beijing, Beijing, China
Guanganmen Hospital, Chinese Academy of Traditional Chinese Medicine
🇨🇳Beijing, Beijing, China
The fisrt affiliated hospital of Wenzhou medical university
🇨🇳Wenzhou, Zhejiang, China
The first affiliated hospital of Dalian medical university
🇨🇳Dalian, Liangning, China
Shanghai Renji hospital
🇨🇳Shanghai, Shanghai, China
Wuhan union hospital
🇨🇳Wuhan, Hubei, China
Xuzhou third people's hospital
🇨🇳Xuzhou, Jiangsu, China
Shanghai East hospital
🇨🇳Shanghai, Shanghai, China