Coronary Artery Calcification Assessed on PET Scanner (PET : Positron Emission Tomography)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Coronary Artery Disease
- Sponsor
- Centre Hospitalier Régional d'Orléans
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- Prevalence of moderate calcification artery calcium (CAC) in participants without history of cardiac disease
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
Calcification artery calcium (CAC) scoring is a valuable tool for determining the risk of major adverse cardiac events.
It was found that CAC can be quantitatively assessed, by manual scoring or using deep-learning, on low-dose non electrocardiogram-gated, contrast-enhanced or non-enhanced computed tomography (CT-scan) performed in association of PET acquisition, with a good agreement with standard scans.
The purpose of this study is to determine the impact of a systematic coronary artery calcification evaluation in patients undergoing flourine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) imaging to improve primary prevention of cardiovascular diseases.
A visual calcification artery calcium assessment will be made for each patient, dividing them into four groups: none, mild, moderate or heavy calcification artery calcium. When possible, a calcification artery calcium score will be computed.
Each patient will complete a questionnaire to collect risk factors, history of cardiovascular diseases and medications.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients referred for a 18F-FDG PT/CT imaging
- •Patients aged 18 and older
Exclusion Criteria
- •Patients who already participated in this study (in case of follow-up PET/CT scans)
- •Unusable CT scan due to CT artifacts or poor-quality images
- •Patients referred for a brain 18F-FDG PET/CT imaging
- •Protected adults
- •Pregnant or breastfeeding women
Outcomes
Primary Outcomes
Prevalence of moderate calcification artery calcium (CAC) in participants without history of cardiac disease
Time Frame: Baseline
In participants who had neither history of cardiac disease nor cardiology follow-up, the proportion of those with at least moderate CAC
Secondary Outcomes
- Prevalence of coronary heart disease among participants(Baseline)
- Prevalence of moderate CAC in participants not taking low-cholesterol drug(Baseline)
- Correlation of CAC with the medical indication for PET imaging(Baseline)
- Prevalence of CAC in young participants (< 45 years old)(Baseline)
- Prevalence of no CAC in participants taking statins(Baseline)