Development, Implementation and Initiation of Normative Database Quantitative Ultra High Field MRI Paramaters
试验速览
- 阶段
- 不适用
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- qualitative validation concerning structure visible with high field MRI
研究概览
简要总结
The Centre for Magnetic Resonance in Biology and Medicine (CRMBM, UMR-CNRS 7339 AMU) obtained funding for a whole body NMR imaging at 7. It is the only MRI at 7T installed in a hospital in France (only two 7T MRI in France) and therefore a unique opportunity to develop new diagnostic approaches.
The purpose of this study is to develop, implement and validate new MRI quantitative parameters derived from ultra high field MRI in order to characterize non-invasively with an unprecedented resolution and sensitivity, anatomy as well as certain physiological, hemodynamic and metabolic function of brain, spinal cord, musculoskeletal system, and heart in healthy subjects
详细描述
The key is that the goal of our projects is not only producing images of better quality than using a 3T scanner but also making images differently, by highlighting new contrasts and features of theses organs in order to improve the diagnosis and prognosis of neurological, psychiatric, cardiovascular and rheumatologic diseases.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •People not presenting contraindications to the MRI (pacemaker, agitation, metallic brightness, claustrophobia etc.)
- •People having no intra-physical object potentially conductive.
- •People having no affection after detailed interrogation
排除标准
- •People staying in a sanitary or social establishment
- •People in emergency situation
- •People not wishing to be informed about anomalies in the MRI
- •Pregnancy
研究组 & 干预措施
Acquisition of normative database
Development, implementation and initiation of normative database (image and data) quantitative ultra high field MRI paramaters
干预措施: acquisition of normative database with ultra high field MRI (Procedure)
Acquisition of normative database
Development, implementation and initiation of normative database (image and data) quantitative ultra high field MRI paramaters
干预措施: MRI (Device)
结局指标
主要结局
qualitative validation concerning structure visible with high field MRI
时间窗: 4 years
the validation criteria are qualitative (contrast and visibility of anatomical structures usually visible 7T but not visible at 3T will be used to assess the sensitivity of images for each modality) and quantitative (signal to noise ratio (SNR), spatial and temporal resolution).
次要结局
- acquisition of normative data and verification of the quality criteria obtained during the first phase(4 years)