NCT05882084招募中不适用
Double Blind Placebo Controlled Oral Supplementation of Astaxanthin on Skin Photoaging, Hydration and Elasticity
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Skin Hydration
研究概览
简要总结
This study is a double-blind placebo controlled study to assess whether oral astaxanthin can improve skin hydration, skin elasticity, improve skin pigmentation, and reduce facial redness.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 30 Years 至 55 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Females who are 30 to 55 years of age
- •Half of the women will have Fitzpatrick skin type 1-3 and the other half of the women will have Fitzpatrick skin type 4-6
排除标准
- •Individuals with a known allergy to astaxanthin or other carotenoids (such as zeaxanthin, lutein, lycopene).
- •Individuals who are unwilling to discontinue carotenoid supplementation for at least 1 month prior to enrollment
- •Individuals unwilling to restrict intake of foods like shrimp, salmon, mangos, carrots, and tomatoes during the study.
- •New supplementation within 4 weeks with tocopherol
- •Individuals who are unwilling to stay consistent with a facial cleansing regimen.
- •Those who are unwilling to discontinue topical hydroquinone, retinoid or benzoyl peroxide for 2 weeks prior to enrollment
- •Individuals who are pregnant or breastfeeding.
- •Individuals who have changed any of their hormonal based contraception within 3 months prior to joining the study.
- •Current tobacco smoker or a tobacco smoking history of greater than 10 pack-years
研究组 & 干预措施
Astaxanthin
Experimental
6 mg daily
干预措施: Astaxanthin 6 mg daily (Dietary Supplement)
Placebo
Placebo Comparator
干预措施: Placebo (Dietary Supplement)
结局指标
主要结局
Skin Hydration
时间窗: 8 weeks
Skin hydration measured with a non-invasive device, SkinMoistureMeterSC
Skin elasticity
时间窗: 8 weeks
Skin elasticity measured with a non-invasive device, Skin Elastimeter
次要结局
- Facial pigmentation(8 weeks)
- Facial redness(8 weeks)
研究者
Raja Sivamani, MD MS AP
Principal Investigator
Integrative Skin Science and Research
研究点 (1)
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