Microscopy Imaging of Whole-mount Stained Human Tissues

Recruiting

• Conditions: Tumor, Breast; Tumor, Brain; Tumor Skin

• Registration Number: NCT05689112
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

The goal of this clinical trial is to develop an imaging platform for intraoperative tumor margin delineation in 250 cases of tumor-suffered patients. The main questions it aims to answer are:

• to develop the protocol of rapid assessment of surgical specimens without need for fixation, embedding, and cryosectioning required for conventional histopathology.

Participants will provide a small piece of their surgical specimens from tumor removal surgery .

If there is a comparison group: Researchers will compare normal specimens to see if we can observe the difference.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2023-01-09
• Study First Submitted QC: 2023-01-09
• Study Start: 2023-01-10
• Study First Posted: 2023-01-18
• Status Verified: 2024-01
• Last Update Submitted: 2024-08-19
• Last Update Posted: 2024-08-21
• Primary Completion: 2025-12-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 250

Inclusion Criteria

1. Patients who are more than 20 years old.
2. Diagnosed as patients suffered by skin tumor, brain tumor and breast tumor.

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Exclusion Criteria

1. Patients who can't speak and communicate with others.
2. Patients who can't make eventual and exact pathological assessment for his/her diseases.
3. Patients who only can fit for slicing tumor.
4. Removed tissues which obviously vary after severe ray radiation under microscopy observation.
5. Diameter of tumors are under 1 centimeter.
6. Breast carcinoma in situ.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The assessment between tumor cases and control cases	5 years	Do comparison with images acquired by our microscopy (with the whole-mount staining method) and bright field microscopy (with standard FFPE method) and do assessment to interpret tumor characteristics

Trial Locations

Locations (1)

Department of Dermatology, National Taiwan University Hospital and College of Medicine, National Taiwan University; 🇨🇳 Taipei, Taiwan