Importance of Aldosterone in the Pathogenesis of Hypertensive Heart Disease

Phase 3

Completed

• Conditions: Primary Hypertension
• Interventions: Drug: placebo; Drug: spironolactone

• Registration Number: NCT00865501
• Lead Sponsor: University of Erlangen-Nürnberg Medical School

Brief Summary

The Renin-Angiotensin-Aldosterone-system is important in the development of cardiovascular organ damage caused by arterial hypertension. This study aims at evaluating the importance of aldosterone with regard to hypertension induced damage to the heart. In order to do this the investigators will perform a comparative cross-sectional study in hypertensives and normotensives. In addition as interventional part the hypertensives will be treated with a mineralocorticoid-receptor blocker (spironolactone).

Detailed Description

Not available

Study Timeline

• Study Start: 2008-03
• Study First Submitted: 2009-03-18
• Study First Submitted QC: 2009-03-18
• Study First Posted: 2009-03-19
• Primary Completion: 2009-12
• Study Completion: 2009-12
• Status Verified: 2012-07
• Last Update Submitted: 2012-07-06
• Last Update Posted: 2012-07-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 50

Inclusion Criteria

• Clinical diagnosis hypertension (BP higher than 139/89)

Exclusion Criteria

• Antihypertensive pretreatment
• Contraindications against spironolactone
• Being unable to understand or comply with study procedures

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
2	placebo	placebo
1	spironolactone	spironolactone

Primary Outcome Measures

Name	Time	Method
left ventricular mass	8 weeks

Trial Locations

Locations (1)

University Erlangen-Nürnberg, Nephrology and Hypertension; 🇩🇪 Erlangen, Germany