NCT00865501已完成3 期
Importance of Aldosterone in the Pathogenesis of Hypertensive Heart Disease
University of Erlangen-Nürnberg Medical School1 个研究点 分布在 1 个国家目标入组 50 人开始时间: 2008年3月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- left ventricular mass
研究概览
简要总结
The Renin-Angiotensin-Aldosterone-system is important in the development of cardiovascular organ damage caused by arterial hypertension. This study aims at evaluating the importance of aldosterone with regard to hypertension induced damage to the heart. In order to do this the investigators will perform a comparative cross-sectional study in hypertensives and normotensives. In addition as interventional part the hypertensives will be treated with a mineralocorticoid-receptor blocker (spironolactone).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis hypertension (BP higher than 139/89)
排除标准
- •Antihypertensive pretreatment
- •Contraindications against spironolactone
- •Being unable to understand or comply with study procedures
研究组 & 干预措施
1
Experimental
spironolactone
干预措施: spironolactone (Drug)
2
Placebo Comparator
placebo
干预措施: placebo (Drug)
结局指标
主要结局
left ventricular mass
时间窗: 8 weeks
次要结局
未报告次要终点
研究者
研究点 (1)
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