Hypertonic Saline Inhalation in Acute Bronchiolitis
- Conditions
- Acute Bronchiolitis
- Interventions
- Drug: normal saline and salbutamolDrug: hypertonic saline and salbutamolDrug: Hypertonic saline
- Registration Number
- NCT03880903
- Lead Sponsor
- Assiut University
- Brief Summary
Acute bronchiolitis is a viral infection that occurs in children most commonly in the first 2 years of life and is characterized by respiratory symptoms, resulting in wheezing and/or crackles upon auscultation. It is usually a self limiting illness. However, this condition may be associated with several severe complications, such as apnea,respiratory failure, or secondary bacterial infection
- Detailed Description
Acute bronchiolitis is a viral infection that occurs in children most commonly in the first 2 years of life and is characterized by respiratory symptoms, resulting in wheezing and/or crackles upon auscultation. It is usually a self limiting illness. However, this condition may be associated with several severe complications, such as apnea,respiratory failure, or secondary bacterial infection. Bronchiolitis is a significant cause of respiratory disease worldwide. according to the World Health Organization bullet in, an estimated 150 million new cases occur annually; 11-20 million (7-13%) of these cases are severe enough to require hospital admission. Worldwide, 95% of all cases occur in developing countries. Typically, initial clinical manifestations include upper respiratory tract symptoms such as cough, nasal congestion, and low-grade fever lasting 1 to 3 days, followed by expiratory wheezing, nasal flaring, fine crackles, oxygen saturation on presentation\<94%, tachypnea, increased work of breathing, use of accessory muscles, and retractions in some patients. The need for hospitalization depends on the presence of respiratory symptoms (degree of retractions, increased respiratory effort, decreased oxygen saturation), cyanosis, restlessness or lethargy, and underlying disease states, including apnea. Since no definitive antiviral therapy exists for most causes of bronchiolitis, management of these infants should be directed toward symptomatic relief and maintenance of hydration and oxygenation. One medication that has demonstrated promising results in the management of acute bronchiolitis is nebulized hypertonic saline , Its hyperosmolarity helps to absorb water from the mucosal and submucosal space, thereby increasing mucociliary function by clearing fluids accumulated in the airway and mucus plugs in the lungs. Hypertonic saline can also induce cough to help enhance mucus clearance. The American Academy Of Pediatrics guidelines recommend administration of hypertonic saline in hospitalized bronchiolitis patients. The most common dosage studied is hypertonic saline 3% 4 mL per dose inhaled by nebulizer every 4 to 6 hours, which may take ≥24 hours to work and is typically continued while the child is hospitalized.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 75
- infants less than 24 months of age with adiagnosis of acute bronchiolitis
- other infants and children above 24 months of age
- patients with other diseases than acute bronchiolitis
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description normal saline with bronchdilator normal saline and salbutamol will recieve treatment with nebulized brochodilator(salbutamol) and normal saline every 4 to 6 hours hypertonic saline with bronchodilator hypertonic saline and salbutamol will recieve treatment with nebulized bronchodilator(salbutamol) and hypertonic saline every 4 to 6 hours hypertonic saline only Hypertonic saline will recieve treatment with nebulized hypertonic saline 3% in adose of 4 ml every 4 to 6 hours
- Primary Outcome Measures
Name Time Method Hospital length of stay 24 hours time taken to discharge or ready to be discharged
- Secondary Outcome Measures
Name Time Method