Comparison of the Clinical Efficacy of Intraarticular Glucose Versus Hyaluronic Acid Injection for Knee Osteoarthrosis
Overview
- Phase
- Not Applicable
- Intervention
- glucose water
- Conditions
- Osteoarthritis, Knee
- Sponsor
- Taipei Veterans General Hospital, Taiwan
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)
- Last Updated
- 7 years ago
Overview
Brief Summary
The study is a prospective, randomized controlled, double-blind study. The enrolled patients were randomly divided into two groups: the intraarticular glucose group and the intraarticular HA group.
Detailed Description
The glucose group underwent 3 sessions of 6cc 25% glucose injection with a 2-week interval between each treatment. The HA group was administered intra-articular HA ((Hyruan PlusR, average MW 3000 kD; LG Life Sciences Ltd, Korea)) for sessions with a 1-week interval between each treatment. The results were measured with the visual analogue scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Lequesne index. A baseline for each test was measured before treatment and then the effects of the treatments were measured by each test at 6 and 12 weeks after treatment
Investigators
Eligibility Criteria
Inclusion Criteria
- •people aged 45 years or more;
- •subjects diagnosed with knee OA according to the clinical criteria of the American College of Rheumatology
- •subjects diagnosed with grade II or III OA during radiological examination as defined by the radiological classification of Kellgren and Lawrence (K-L) scale for knee OA
- •subjects with tenderness in the medial tibial plateau area
Exclusion Criteria
- •. subjects having other illnesses of neurologic diseases, cardiac disorders, hemodynamically unstable systems, or physical functions;
- •. Inflammatory arthritis or subjects with acute knee arthritis
- •. subjects who have received intraarticular injection on the affected knee within the past 3 months.
- •. subjects with previous medical histories involving the affected knee such as surgeries, cancer and maligament tumors.
Arms & Interventions
Glucose group
The glucose group underwent 3 sessions of 6cc 25% glucose injection with a 2-week interval between each treatment
Intervention: glucose water
hyaluronic acid group
The HA group was administered intra-articular HA ((Hyruan Plus® , average MW 3000 kD; LG Life Sciences Ltd, Korea)) for sessions with a 1-week interval between each treatment.
Intervention: hyaluronic aicd
Outcomes
Primary Outcomes
Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)
Time Frame: 12 weeks
The Western Ontario and McMaster Universities Arthritis Index (WOMAC) is widely used in the evaluation of Hip and Knee Osteoarthritis. It is a self-administered questionnaire consisting of 24 items divided into 3 subscales
Secondary Outcomes
- Lequesne index(0,6,12 weeks)
- visual analogue scale (VAS)(0,6,12 weeks)