Evaluation of the medium to long term impact of commercial open-group behavioural weight loss programmes on body weight and diabetes risk in adults with overweight and obesity: 5 & 10 year follow up of the WRAP trial

Not Applicable

• Conditions: Obesity, diabetes; Nutritional, Metabolic, Endocrine

• Registration Number: ISRCTN64986150
• Lead Sponsor: niversity of Cambridge

Brief Summary

2021 Results article in https://pubmed.ncbi.nlm.nih.gov/34743721/ secondary analysis (added 10/11/2021) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/36182236/ (added 03/10/2022)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-02-01
• Last Update Posted: 17 October 2022
• Study Completion: 2024-03-31

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 1040

Inclusion Criteria

Participants who took part in the original WRAP study and consented for further follow up

Exclusion Criteria

Does not meet inclusion criteria

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
5 year (and 10 year) changes in weight, adjusted for baseline. Participants will be weighed at their local GP surgery using calibrated scales. Where participants are unable/unwilling to attend a visit the trialists will obtain a weight measurement from NHS records and/or self-report.

Secondary Outcome Measures

Name	Time	Method
<br> 5 year changes (and 10 year changes) in:<br> 1. Fat mass, measured by Tanita body composition analyser<br> 2. HbA1C and lipid profile, measured by blood sample and analysed used standardised methods<br> 3. Blood pressure, measured using OMRON meter in a resting state<br> 4. Diabetes status (normoglycaemia, non-diabetic hyperglycaemia and diabetes)<br> 5. Modelled 10-year cardiovascular risk (Q-Risk)<br>