The Effects of Weight Loss on Psoriatic Arthritis

Not Applicable

Completed

• Conditions: Obesity; Psoriatic Arthritis
• Interventions: Behavioral: diet and biopsychosocial exercise intervention

• Registration Number: NCT05393141
• Lead Sponsor: Hacettepe University

Brief Summary

Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis. Although the underlying cause of PSA is unclear, increased body weight is known to increase the disease symptoms. This study aims to determine the effects of dietary and Cognitive Exercise Therapy Approach (BETY-Bilişsel Egzersiz Terapi Yöntemi) interventions on symptoms. Accordingly, 45 overweight/obese subjects with PSA aged 20-65 years will divide into "diet", "diet+bety", and "control" groups. Dietary, laboratory and anthropometric records, Short Form Health Survey, DAPSA (Disease Activity in Psoriatic Arthritis), HAQ (Health Assesment Questionnaire) of all subjects will compare at the baseline and at the end of the study.

Detailed Description

Although the underlying cause of PSA is unclear, increased body weight is known to increase the disease symptoms. The present study aims to determine the effects of dietary and Cognitive Exercise Therapy Approach interventions on symptoms.

* Fourt-five overweight/obese subjects with PSA aged 20-65 years will divide into diet (n=15), diet+bety (n=15), and control (n=15) groups.

* Individually diet programs will be applied according to the metabolic, biochemical, and physical activity status of the subjects prepared by a registered dietitian.

* BETY exercise training will be given by a registered physiotherapist.

* The subjects will be followed for 12 weeks.

* Dietary, laboratory and anthropometric records, Short Form Health Survey, DAPSA (Disease Activity in Psoriatic Arthritis), HAQ (Health Assesment Questionnaire) of all subjects will compare at the baseline and at study completion.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2022-01-30
• Study First Submitted: 2022-05-23
• Study First Submitted QC: 2022-05-23
• Study First Posted: 2022-05-26
• Primary Completion: 2022-08-15
• Study Completion: 2022-10-15
• Status Verified: 2022-12
• Last Update Submitted: 2022-12-04
• Last Update Posted: 2022-12-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

• overweight/obese
• diagnosed with PSA

Exclusion Criteria

• pregnancy or lactation

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
diet group	diet and biopsychosocial exercise intervention	weight loss diet intervention for 12 weeks
diet+bety group	diet and biopsychosocial exercise intervention	weight loss diet intervention for 12 weeks and exercise-based biopsychosocial approach (Cognitive Exercise Therapy Approach-BETY) intervention for 12 weeks

Primary Outcome Measures

Name	Time	Method
Weight Loss	At the end of 3 months	BMI (kilogram/metre2(kg/m2))
DAPSA score	At the end of 3 months	The score ranges from 0 to 50 points, with increased score reflect more discomfort

Secondary Outcome Measures

Name	Time	Method
Quality of Life Score	At the end of 3 months	The score ranges from 0 to 100 points, with increased score reflecting improved quality of life

Trial Locations

Locations (1)

Sümeyra Öteleş; 🇹🇷 Ankara, Turkey