Expression of Trefoil Factors 2 and 3 and Adrenomedullin in Unstimulated Saliva Samples of Chronic Periodontitis Subjects With and Without Coronary Heart Disease
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 75
- 试验地点
- 1
- 主要终点
- Trefoil factors 2 and 3 and Adrenomedullin expression in Chronic periodontitis patients with and without coronary heart disease
研究概览
简要总结
To assess the demographic variables, periodontal parameters and to determine the expression of Trefoil factors 2 and 3 and Adrenomedullin in unstimulated saliva samples of periodontally healthy subjects with coronary heart disease and generalised chronic periodontitis subjects with and without coronary heart disease.
详细描述
A total of 75 subjects will be recruited for the study based on the power of the study.
The selected subjects will be divided into 3 groups based on inclusion and exclusion criteria.
GROUP I:25Generalized chronic periodontitis subjects without coronary heart disease.
GROUP II: 25Generalized chronic periodontitis subjects diagnosed with coronary heart disease.
GROUP III: 25Periodontally healthy subjects diagnosed with coronary heart disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Other
入排标准
- 年龄范围
- 30 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients willing to participate in the study.
- •Patients within the age group of 30-65 years.
- •Patients should have ≥ 20 remaining natural teeth.
- •For Group I
- •Systemically healthy, Generalized chronic periodontitis subjects with 30% or more sites with clinical attachment loss (CAL) ≥ 2mm, radiographic evidence of alveolar crestal bone loss ≥ 2mm from the cemento-enamel junction.
- •For Group II
- •Generalized chronic periodontitis subjects with 30% or more sites with clinical attachment loss (CAL) ≥ 2mm, radiographic evidence of alveolar crestal bone loss ≥ 2mm from the cemento-enamel junction along with coronary heart disease.
- •For Group III • Periodontally healthy subjects with Probing pocket depth (PD) less than 4mm, bleeding on probing (BOP) at ≤15% of tooth sites, no periodontal treatment (Scaling and root planing or periodontal surgery) within the previous 6 months and without evident clinical signs of gingival inflammation along with the presence of coronary heart disease.
排除标准
- •Subjects with systemic conditions such as type I and type II diabetes mellitus, respiratory diseases, renal disease, liver disease, rheumatoid arthritis, allergy, advanced malignancies and HIV infection will be excluded from the present investigation.
- •For Group I, subjects on drugs such as corticosteroids, antibiotics, within 6 months of investigation will be excluded.
- •Current smokers and individuals who quit smoking less than 6 months.
- •Patients who have undergone periodontal therapy within the previous 6 months.
- •Pregnant women (pregnancy may alter the oral flora)
结局指标
主要结局
Trefoil factors 2 and 3 and Adrenomedullin expression in Chronic periodontitis patients with and without coronary heart disease
时间窗: 12 months
Expression of Trefoil factors 2 and 3 and Adrenomedullin using Enzyme Linked Immunosorbent Assay
次要结局
未报告次要终点
研究者
Dr.Jaideep Mahendra
Professor, PhD guide, Director of Post Graduate Studies
Meenakshi Ammal Dental College and Hospital