A study to test an oral medicine, belumosudil, in combination with corticosteroids in participants at least 12 years of age with newly diagnosed chronic graft versus host disease.
- Conditions
- chronic graft versus host diseaseMedDRA version: 20.1Level: PTClassification code: 10066261Term: Chronic graft versus host disease Class: 100000004870Therapeutic area: Diseases [C] - Immune System Diseases [C20]
- Registration Number
- CTIS2023-505394-32-00
- Lead Sponsor
- Sanofi-Aventis Recherche & Developpement
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 320
Patients must be at least 12 years of age inclusive, at the time of signing the informed consent, Participants who have undergone allogenic HCT with newly diagnosed moderate to severe cGVHD according to NIH consensus diagnosis and staging criteria (2014), Participants who require systemic treatment with corticosteroids for cGVHD, Participants who have not received any prior systemic treatment for cGVHD (including ECP), If participants are receiving other immunosuppressive agents for the prophylaxis or treatment of acute GVHD, the dose should be under the threshold pre-defined in protocol, Body weight = 40kg, Contraceptive use by men and women should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies., Participants or their legally authorized representative must be capable of giving signed informed consent
Histological relapse of the underlying disease after most recent allogeneic HCT, Active uncontrolled cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infection. Infections are considered controlled if appropriate therapy has been instituted and, at the time of screening, no signs of infection worsening are present according to Investigator’s judgement, Diagnosed or treated for another malignancy other than the underlying disease allogeneic HCT was indicated for, within 3 years prior to randomization with the exception of complete resection of basal cell carcinoma or squamous cell carcinoma of the skin, an in-situ malignancy, or low risk prostate cancer after curative therapy, Post-transplant lymphoproliferative disease within 4 weeks prior to randomization, Unable to swallow tablets, Participant not suitable for participation, whatever the reason, as judged by the Investigator, including medical or clinical conditions, or participants potentially at risk of noncompliance to study procedures, Female participants who are pregnant or breastfeeding, Unable to tolerate a prednisone equivalent dose of corticosteroids = 1 mg/kg/day, Participant has had previous exposure to belumosudil., Received any previous systemic treatment for cGVHD with the following exception: Corticosteroids for cGVHD received within 7 days prior to the planned administration of IMP only if in the interest of participant., Received any investigational agents, or any investigational device or procedure, or prohibited therapy for this study within 28 days or 5 elimination half-lives prior to randomization, whichever is longer, Absolute neutrophil count (ANC) <1.0 x 109/L. The use of granulocyte-colony stimulating factor (G-CSF) is not allowed to reach this level during screening, Karnofsky (if aged =16 years)/Lansky (if aged <16 years) Performance Score of < 60, Platelets <50 x 109/L. Platelet transfusion is not allowed within 3 days before the screening hematological test, Any active, uncontrolled infections assessed to be clinically significant by the Investigator, Estimated Glomerular Filtration Rate (eGFR) <30 mL/min/1.73 m2 using the MDRD-4 variable formula (if aged =18 years) or using the Bedside Schwartz formula (if aged <18 years), Aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) >3 x ULN without liver cGVHD (or >5 × ULN if due to cGVHD with liver cGVHD), Total bilirubin >1.5 × (ULN) (>3 × ULN if Gilbert syndrome), Participant has forced expiratory volume in 1 second (FEV1) of predicted =39% or has lung score of 3 according to NIH consensus diagnostic and staging criteria (2014), History or other evidence of severe illness or any other conditions that would make the participant, in the opinion of the Investigator, unsuitable for the study (such as malabsorption syndromes, poorly controlled psychiatric disease or coronary artery disease), Known history of human immunodeficiency virus (HIV), Active viral disease including hepatitis B virus (HBV) or hepatitis C virus (HCV)
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main Objective: Demonstrate the superiority of belumosudil in combination with prednisone vs prednisone alone in Event-Free Survival (EFS);Secondary Objective: Demonstrate the superiority of belumosudil in combination with prednisone vs prednisone alone in modified Lee Symptom Scale (mLSS) improvement, Demonstrate the superiority of belumosudil in combination with prednisone vs prednisone alone in durable overall response rate (ORR), Demonstrate the superiority of belumosudil in combination with prednisone vs prednisone alone in the rate of corticosteroid withdrawal, Overall response rate (ORR), ORR by 24 weeks, Duration of response (DOR), Dose reduction in corticosteroid, Failure Free Survival (FFS), Change in patient reported outcome (PRO), Safety, Overall survival;Primary end point(s): Event-Free Survival (EFS) from the date of randomization to the date of any predefined event, whichever occurs first
- Secondary Outcome Measures
Name Time Method