NCT04435223已完成不适用
Lipid Metabolism in COVID-19 Severe Pneumonia Compared With Severe Pneumonia Caused by Other Pathogen
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 62
- 试验地点
- 1
- 主要终点
- Cholesterol concentration
研究概览
简要总结
SARS-COV 2 infection might be responsible for sever pneumonia. Obesity seems to be a risk factor for severe SARS-COV 2 pneumonia. Lipid metabolism alteration are described with both obesity and sepsis. The aim of the present study was to describe association between lipid metabolism, obesity, sepsis inflammation and clinical outcome in COVID-19 patient with severe pneumonia compared with severe pneumonia caused by other pathogenes.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •2 of the following criteria: Cough/ Dyspnea/ Spitting/ Thoracic pain/ Hyperthermia (>=38 °C) Hypothermia (< 35°C) AND new radiologic pulmonary infiltrate
- •At admission or within 48 hours following hospital admission
- •With 2 qSOFA criteria: MAP =< 100 mmHg, Respiratory Rate >= 22, Glasgow score < 15 OR on mechanical ventilation OR under vasopressor
- •Age > 18
- •affiliated to social security
排除标准
- •Pregnancy
- •immunodepression
- •Pathology known to cause severe lymphopenia
- •hospitalisation within 3 month before inclusion AND sepsis
研究组 & 干预措施
COVID-19 severe pneumonia
干预措施: biological assays in particular on the lipid metabolism (Biological)
Severe pneumonia due to other pathogene
干预措施: biological assays in particular on the lipid metabolism (Biological)
结局指标
主要结局
Cholesterol concentration
时间窗: Within 48 hours following hospital admission
次要结局
- LDL cholesterol / HDL cholesterol/ Lipoprotein size and composition/ Non esterified Fatty acid/ Triglyceridemia/ CETP and PLTP activity/ apolipoprotein canceration/ lipid peroxidation/ Pro and anti inflammatory profile.(Within 48 hours following hospital admission)
研究者
研究点 (1)
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