Modulation of Painful Perception

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Device: thermal stimulation delivered by a thermode.; Other: functional MRI

• Registration Number: NCT02528578
• Lead Sponsor: Centre Hospitalier Universitaire de Saint Etienne

Brief Summary

The objective of the study is to evaluate in healthy volunteers, the influence of empathy on pain perception.

It is widely accepted in the clinical management that the feeling of listening to the patients' pain would have a favorable influence on the pain, and conversely, the lack of listening would be aggravating.

In this study, the volunteer will receive painful thermal stimuli in empathetic context (l, empathetic or non-empathetic) Two situations will oppose, one where the examiner neglect or minimize the suffering of the voluntary and the other or the contrary, the subject will receive empathy.

The first part of the project is to verify that the pain is influenced by the empathetic context. The second part will be conducted functional MRI, which should isolate the brain regions affected by other people's empathy for pain.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-06
• Study First Submitted: 2015-08-17
• Study First Submitted QC: 2015-08-18
• Study First Posted: 2015-08-19
• Primary Completion: 2015-11
• Study Completion: 2015-11
• Status Verified: 2016-09
• Last Update Submitted: 2017-09-25
• Last Update Posted: 2017-09-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 74

Inclusion Criteria

• Right handed

Exclusion Criteria

• Pregnant or lactating women,
• Against-indications to MRI
• Drug intake of less than 12 hours,
• Neurological history or deficits, psychiatric, auditory or visual.
• Decline to participate

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
healthy volunteers	functional MRI	-
healthy volunteers	thermal stimulation delivered by a thermode.	-

Primary Outcome Measures

Name	Time	Method
Intensity of the perceived pain assessed by the volunteer by a analog scale (VAS) at each thermal stimulation.	Day 0

Secondary Outcome Measures

Name	Time	Method
blood-oxygen-level dependent (MRI)	Day 0

Trial Locations

Locations (2)

CHU de SAINT-ETIENNE; 🇫🇷 Saint-etienne, France

Hospices Civils de LYON; 🇫🇷 Lyon, France