Indocyanine-green Mediated Photosensitizer VS Aloe Vera Gel: Adjunct Therapy to Scaling and Root Planing in Patients With Chronic Periodontitis
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 150
- 试验地点
- 2
- 主要终点
- Clinically Evaluating the Effects of Topical Indocyanine-green Mediated Photosensitizer VS Aloe vera Gel: Adjunct therapy to Scaling and Root Planing in Patients with Chronic Periodontitis
研究概览
简要总结
For proving the potential of tropical medicaments on clinical parameters of periodontitis, a comprehensive assessment is required between therapeutic medicaments. The main aim of the study was to clinically evaluate and compare the efficacy of indocyanine green mediated photodynamic therapy (PDT) and aleo vera (AV) extract when used as an adjunct therapy to scaling and root planning (SRP) for treatment of chronic periodontitis.
One hundred and fifty patients included in this study were randomly distributed in three treatment groups Group I (SRP), Group II (SRP+PDT) and Group III (SRP+AV). Four clinical parameters plaque index (PI), bleeding on probing (BoP), periodontal (PD) pocket depth and clinical attachment level (CAL) were evaluated at three time points baseline, 3rd and 6th month respectively. Additionally the amount of three inflammatory cytokines IL-6, IL-8 and TNF- α in gingival crevicular fluid (GCF) was identified using enzyme linked immune-sorbent assay (ELISA) technique.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 30 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age of ≥ 30 years;
- •≥ 20 natural teeth; and
- •chronic-periodontitis (≥ 3 mm of CAL and PD pocket depth respectively on at least 30% of dental sites).
排除标准
- •chronic systemic diseases;
- •PD therapy during last 6 months;
- •habitual use of chewable and non-chewable tobacco (smoking);
- •alcohol consumers; or
- •use of particular medications during last three months (steroidal and non-steroidal drugs/ anti-biotic/ anti-depressants)
结局指标
主要结局
Clinically Evaluating the Effects of Topical Indocyanine-green Mediated Photosensitizer VS Aloe vera Gel: Adjunct therapy to Scaling and Root Planing in Patients with Chronic Periodontitis
时间窗: 9 months
Adjunct treatment regimens PDT and AV extract significantly helped in plummeting inflammation of PD tissue
IL-6 concentration in pg/ml
时间窗: 6 months
Identify the concentration of IL-6 in the gingival crevicular fluid
Clinical attachment loss in mm
时间窗: 6 months
Periodontal attachment loss
TNF-α levels in pg/ml
时间窗: 6 months
Identify the concentration of TNF-α in the gingival crevicular fluid
IL-8 concentration in pg/ml
时间窗: 6 months
Identify the concentration of IL-8 in the gingival crevicular fluid
Periodontal pocket depth in mm
时间窗: 6 months
Periodontal pocket depth
次要结局
未报告次要终点
研究者
Zeeshan Qamar
Assistant Professor
Riyadh Elm University