The Role of Nitric Oxide Synthase Isoforms in the Cardiovascular Effects of Air Pollution
- Conditions
- Endothelial Dysfunction
- Registration Number
- NCT00845169
- Lead Sponsor
- University of Edinburgh
- Brief Summary
Exposure to air pollution has been linked to increased cardiorespiratory morbidity and mortality. The exact component of air pollution that mediates this effect is unknown, but the link is strongest for fine combustion derived particulate matter derived from traffic sources. Recently, it has been demonstrated that inhalation of diesel exhaust impairs vascular vasomotor tone and endogenous fibrinolysis. The mechanism underlying these detrimental vascular is unclear, but is thought to be via oxidative stress and altered bioavailability of endogenous nitric oxide. In these studies we plan to elucidate the role of endogenous nitric oxide synthase isoforms (NO) in the adverse vascular responses observed following exposure to diesel exhaust.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 16
- Healthy volunteers
- Regular medication use (except oral contraceptive pill)
- Current smokers
- Significant occupational exposure to air pollution
- Intercurrent illness
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Forearm blood flow measured by venous occlusion plethysmography during intraarterial infusion of nitric oxide synthase inhibitors L-NMMA, SMTC and 1400W and positive control norepinephrine. 2-4 hours after exposure
- Secondary Outcome Measures
Name Time Method Plasma nitrite concentration During forearm study
Trial Locations
- Locations (1)
Umeå University
🇸🇪Umeå, Sweden
Umeå University🇸🇪Umeå, Sweden