跳至主要内容
临床试验/NCT06488183
NCT06488183招募中不适用

Laparoscopic Preperitoneal Local Anesthetic Infiltration Versus Ultrasound Guided Quadratus Lumborum Block in Laparoscopic Bariatric Surgery

sarah mohamed1 个研究点 分布在 1 个国家目标入组 44 人开始时间: 2024年5月12日最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
发起方
入组人数
44
试验地点
1
主要终点
postoperative pain score

研究概览

简要总结

preperitoneal local anesthetic infiltration is effective for relief of postoperative pain in patients undergoing laparoscopic bariatric surgery.

详细描述

Obesity and overweight have become a global epidemic, impacting people of all ages and socioeconomic status. Obesity is still a major public health issue globally, despite progress in some places. Bariatric surgery remains the most effective and long-lasting way to lose weight and address obesity-related conditions.(1) Optimizing postoperative pain treatment is crucial for reducing complications, shortening hospital stays, and lowering expenditures in patients undergoing surgery. Multimodal analgesia and postoperative pain reduction are especially relevant to bariatric surgery patients, who frequently have numerous coexisting conditions and are more vulnerable to thrombotic and respiratory problems. Obstructive sleep apnea (OSA) is common among obese individuals, making safe analgesic treatment problematic. Controlling pain following bariatric surgery is particularly difficult. General management recommendations include multimodal analgesic therapy, regional methods, avoidance of sedatives and early mobilization.(2, 3, 4, 5)

Blanco originally described the quadratus lumborum block (QLB) in 2007. The primary benefit of QLB is the extension of a local anesthetic agent beyond the transversus abdominis plane into the thoracic paravertebral area. The greater distribution of local anesthetic agents may provide significant analgesia and prolong the action of the injected local anesthetic solution.(6)

Preperitoneal local anesthetic injection was initially developed by Dean et al. as a pain management strategy for laparoscopic hernia repair, and it is currently widely used.(7) A recent meta-analysis compared preperitoneal and subcutaneous wound catheters to epidural analgesia. Preperitoneal wound catheters were shown to be as effective as epidural analgesia in abdominal surgeries. Periportal wound catheters appear to be more effective in terms of patient satisfaction and recovery.(8) A recent study concluded that preperitoneal local anesthetic infiltration is effective for relief of postoperative pain in patients undergoing laparoscopic bariatric surgery.(9)

Aim of the work:

The present study aims to compare the analgesic efficacy of ultrasound-guided trans-muscular quadratus lumborum block (QLB) to preperitoneal local anesthetic infiltration during laparoscopic bariatric surgery and in the early postoperative period.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Other
盲法
Double (Participant, Outcomes Assessor)

入排标准

年龄范围
20 Years 至 50 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Age: 20-50 years, both sexes.
  • ASA physical status class I to III.
  • BMI 35-50 kg/m²

排除标准

  • Severe cardiac disorder
  • chronic renal failure
  • liver cirrhosis
  • allergy to bupivacaine
  • patients with history of chronic opioid consumption
  • HBA1C > 7%

结局指标

主要结局

postoperative pain score

时间窗: postoperative day 1

VAS score

次要结局

  • postoperative nausea and vomiting(postoperative day1)
  • length of stay in pacu(postoperative day 1)
  • postoperative morphine requirements(postoperative day 1)
  • Length of hospital stay(postoperative day 3)

研究者

发起方
sarah mohamed
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

sarah mohamed

MD

Alexandria University

研究点 (1)

Loading locations...

相似试验

Laparoscopic Preperitoneal Local Anesthetic... | 临床试验