Longevity Families of the Netherlands
Trial Snapshot
- Phase
- Not Applicable
- Status
- Active, not recruiting
- Sponsor
- Enrollment
- 600
- Locations
- 1
- Primary Endpoint
- Identifying the genetic variants of Familial Longevity
Study Overview
Brief Summary
The demographic life expectancy enhancement of the past 150 years imposes an urgent challenge in Western and economically growing societies to stimulate the healthy lifespan that is lagging behind. Families surviving into exceptionally high ages (longevity) in good physical and mental health illustrate that this is physiologically possible. Such families harbor cross generational socio-genetic mechanisms that mediate healthy aging and protection from (multi)morbidity.
The purpose of our research is: to identify gene variants associated with healthy aging and protection from (multi)morbidity; to study the social-, environment- and behavioral factors of familial longevity, their role in (multi-)morbidity and its interaction with the genetic component.
Study Design
- Study Type
- Observational
- Observational Model
- Family Based
- Time Perspective
- Cross Sectional
Eligibility Criteria
- Ages
- 75 Years to — (Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Siblings of Dutch Caucasian descent age 75+ enriched for familial longevity
- •Individuals of Dutch Caucasian descent age 75+ who are not enriched for familial longevity
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Identifying the genetic variants of Familial Longevity
Time Frame: through study completion, an average of 2 years
To identify gene variants associated with healthy aging and protection from (multi)morbidity
Secondary Outcomes
- Studying the environmental factor of Familial Longevity through questionnaires and its interaction with the genetic component(through study completion, an average of 2 years)
Investigators
Eline Slagboom
Eline Slagboom, Prof. dr.
Leiden University Medical Center