Effectiveness of Chlorhexidine Wipe for Prevention of Multidrug-resistant Organisms in Intensive Care Unit Patients

Phase 3

Completed

• Conditions: Antibiotic Resistant Infection
• Interventions: Drug: Soap; Drug: 2% chlorhexidine wipe

• Registration Number: NCT01989416
• Lead Sponsor: Mahidol University

Brief Summary

The purpose of this study is to determine 2% chlorhexidine wipes are effective in preventing of colonization of multi-drug resistant bacteria in intensive care unit patients.

Detailed Description

The purpose of this study is to evaluate the usefulness of bathing with chlorhexidine wipe to reduce the risks of multidrug resistant bacteria acquisition and hospital-acquired bloodstream infection among ICU patients

Study Timeline

• Study First Submitted: 2013-10-13
• Study First Submitted QC: 2013-11-14
• Study First Posted: 2013-11-21
• Study Start: 2013-12
• Primary Completion: 2015-01
• Study Completion: 2015-04
• Status Verified: 2015-11
• Last Update Submitted: 2015-11-30
• Last Update Posted: 2015-12-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 481

Inclusion Criteria

• Age > 18 years
• Admission in critical care unit eg. ICU, respiratory care unit, Cardiac care unit with in 24 hours
• Expected duration of critical care unit admission > 48 hours

Exclusion Criteria

• History of chlorhexidine allergy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Soap bathing	Soap	ICU patients will be bathing with soap at least once daily
2% chlorhexidine wipes	2% chlorhexidine wipe	Use 2% chlorhexidine wipes to clean the patient at least once daily

Primary Outcome Measures

Name	Time	Method
The overall rate of Multidrug resistant bacteria acquisition at 7 days after received 2% chlorhexidine wipe bathing versus with soap bathing	7 days after recieved 2% chlorhexidine wipes	7 days after received 2% chlorhexidine wipes,the microbiology laboratory will process surveillance specimens using either standard culture-based at both nostrils, axillar, groins, rectum

Secondary Outcome Measures

Name	Time	Method
The overall rate of hospital-acquired bloodstream infections per 1000 patient-days with chlorhexidine wipe bathing versus with soap bathing	48 hours after recieved 2% chlorhexidine wipes

Trial Locations

Locations (1)

Faculty of Medicine Siriraj Hospital, Mahidol University; 🇹🇭 Bangkok, Thailand