Effectiveness of Chlorhexidine Wipe for Prevention of Multidrug-resistant Organisms in Intensive Care Unit Patients
Trial Snapshot
- Phase
- Phase 3
- Status
- Completed
- Sponsor
- Mahidol University
- Enrollment
- 481
- Locations
- 1
- Primary Endpoint
- The overall rate of Multidrug resistant bacteria acquisition at 7 days after received 2% chlorhexidine wipe bathing versus with soap bathing
Study Overview
Brief Summary
The purpose of this study is to determine 2% chlorhexidine wipes are effective in preventing of colonization of multi-drug resistant bacteria in intensive care unit patients.
Detailed Description
The purpose of this study is to evaluate the usefulness of bathing with chlorhexidine wipe to reduce the risks of multidrug resistant bacteria acquisition and hospital-acquired bloodstream infection among ICU patients
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 95 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Age > 18 years
- •Admission in critical care unit eg. ICU, respiratory care unit, Cardiac care unit with in 24 hours
- •Expected duration of critical care unit admission > 48 hours
Exclusion Criteria
- •History of chlorhexidine allergy
Arms & Interventions
Soap bathing
ICU patients will be bathing with soap at least once daily
Intervention: Soap (Drug)
2% chlorhexidine wipes
Use 2% chlorhexidine wipes to clean the patient at least once daily
Intervention: 2% chlorhexidine wipe (Drug)
Outcomes
Primary Outcomes
The overall rate of Multidrug resistant bacteria acquisition at 7 days after received 2% chlorhexidine wipe bathing versus with soap bathing
Time Frame: 7 days after recieved 2% chlorhexidine wipes
7 days after received 2% chlorhexidine wipes,the microbiology laboratory will process surveillance specimens using either standard culture-based at both nostrils, axillar, groins, rectum
Secondary Outcomes
- The overall rate of hospital-acquired bloodstream infections per 1000 patient-days with chlorhexidine wipe bathing versus with soap bathing(48 hours after recieved 2% chlorhexidine wipes)
Investigators
Adhiratha Boonyasiri
Doctor
Mahidol University