NIRS and DO2i Correlation
- Conditions
- Perfusion; ComplicationsMultiorgan Failure
- Registration Number
- NCT03281707
- Lead Sponsor
- Centro Cardiologico Monzino
- Brief Summary
This study evaluates the association between near infrared spectroscopy (NIRS) and indexed oxygen delivery (DO2i) and their possible correlation with postoperative organ failure.
- Detailed Description
Literature evidences show that levels of DO2i under 262-272 mL/min/m2 during cardiopulmonary by-pass (CPB) are associated with an increased incidence of acute kidney injury (AKI).
Furthermore, it has been demonstrated that keeping a NIRS of 75-80% compared to the basal value reduces the risk of perioperative morbidity. On the other hand, a NIRS \< 50% of basal value seems to be predictive of an increase in morbidity.
All of those studies had been performed during CPB and knowledge lacks in management of DO2i and NIRS before and after CPB.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
- All patients undergoing cardiac surgery with cardiopulmonary by-pass whose have been signed the consent informed
Exclusion Criteria
- Impossibilty to collect a correct continuous cardiac output measure with PiCCO (chronic atrial fibrillation or severe peripheral vasculopaty)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Evaluate the correlation between NIRS and DO2i during cardiac surgery Intraoperative
- Secondary Outcome Measures
Name Time Method Evaluate the correlation between NIRS, DO2i and SOFA score 7 days postoperative