Evaluating The Role of B cell activating factor (BAFF) and proliferation-inducing ligand (APRIL) Levels in Migraine Phases to determine autoimmune Characteristics
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- Quantification of BAFF and APRIL levels in different phases of migraine
研究概览
简要总结
Migraine is a chronic neurological disorder characterized by a throbbing headache, typically on one side of the head, along with symptoms such as nausea, sensitivity to light, and disturbances in autonomic, mental, sensory, and motor functions. There are two subtypes of migraine: migraine with aura and migraine without aura. According to the Global Burden of Disease Study (2015), migraine is the most prevalent neurological condition and the third leading cause of disability worldwide, even though its exact cause is not fully understood. Due to our incomplete understanding of its underlying mechanisms, no specific treatment is available for migraine patients.
Previous research has indicated that levels of CD4+ and CD25+ regulatory T cells are lower in migraine patients compared to healthy volunteers. Furthermore, mutations in the Fox P3 gene were observed in migraine patients, which can lead to impairment in the regulation of Tregulatory cells and may be linked to the early onset of autoimmune dysfunction.
These findings suggest that migraine may be an autoimmune condition. Our current study aims to evaluate the levels of BAFF and APRIL in migraine patients (with and without aura) during the pre-ictal, ictal, and post-ictal phases.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Migraine patients with and without aura Patients who are aged above 18 years.
排除标准
- •1.Patients with additional comorbidity conditions were not allowed to participate.
- •2.Patients who have recently taken any immunosuppressants 3.Pregnant women were excluded 4.Patients with previous head injury.
结局指标
主要结局
Quantification of BAFF and APRIL levels in different phases of migraine
时间窗: BAFF and APRIL levels will be quantified at specific time points during the pre-ictal, ictal, and post-ictal phases of a migraine. However, the exact timing of these phases may vary based on the development of migraine pain in each patient, so precise time points cannot be assured.
次要结局
- Not Applicable(Not applicable)
研究者
Dr Murugesan Arumugam
Sri Ramachandra Institute of Higher Education and Research (DU)