A randomised clinical trial assessing the additional value of ovarian hyperstimulation in intrauterine insemination (IUI) for couples with an abnormal post-coital test (PCT)

Not Applicable

Completed

• Conditions: Subfertility; Pregnancy and Childbirth

• Registration Number: ISRCTN90142795
• Lead Sponsor: Academic Medical Center Amsterdam (The Netherlands)

Brief Summary

2007 Results article in https://pubmed.ncbi.nlm.nih.gov/17561002/ (added 15/07/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2005-07-01
• Study Start: 2006-02-08
• Last Update Posted: 26 July 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 265

Inclusion Criteria

Couples were eligible if they had an abnormal PCT, either due to cervical hostility diagnosed by a well-timed, non-progressive PCT with normal semen parameters or due to a poor semen quality. The spontaneous pregnancy chance in the next year, leaving the result of the PCT out of consideration, was less than 30%.

Exclusion Criteria

All other subfertile couples.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary endpoint was ongoing pregnancy within three cycles of IUI. Ongoing pregnancy was defined as the presence of foetal cardiac activity at transvaginal sonography at a gestational age of at least 12 weeks.

Secondary Outcome Measures

Name	Time	Method
Secondary endpoints were total number of clinical pregnancies, miscarriages and multiple pregnancies.