Study of Efficacy and Safety of Cream Infused With HuangQin (Root of Scutellaria Baicalensis) Extract for the Reduction of Hyperpigmentation

Not Applicable

Completed

• Conditions: Hyperpigmentation; Melanin

• Registration Number: NCT07133204
• Lead Sponsor: Mae Fah Luang University

Brief Summary

The aim of this study is to evaluate the efficacy of a topical cream infused with Scutellaria baicalensis extract in reducing hyperpigmentation on the face.

The study is experimental clinical pilot study as a single group pretest-posttest.

A ROAT is conducted 1 week prior to the experiment. Participant apply the cream on the hypigmented area daily. Facial skin parameters (i.e. melanin index, erythema index) is evaluated at week 0, 1, 2 and 4.

Detailed Description

Not available

Study Timeline

• Study Start: 2025-04-01
• Primary Completion: 2025-06-30
• Study Completion: 2025-07-20
• Status Verified: 2025-08
• Study First Submitted: 2025-08-13
• Study First Submitted QC: 2025-08-13
• Last Update Submitted: 2025-08-13
• Study First Posted: 2025-08-20
• Last Update Posted: 2025-08-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 38

Inclusion Criteria

• Male or Female
• Has at least 1 hyperpigmentation spot (size > 3mm) on either side of the face
• 30-60 y/o
• Fitzpatrick skin types II-IV
• Agrees to use sunscreen SPF50+ and willing to avoid strong sunlight exposure during the study

Exclusion Criteria

• Pregnant or lactating
• Use of whitening products or treatment within 1 month before this study
• Currently using contraceptives
• History of allergy to any ingredient in the intervention cream
• Has skin conditions which can interfere with the measurement (i.e. severe acne, eczema, herpes simplex)
• Severe disease (i.e. immunodeficiency, cancer)
• Enrolled in other clinical study within 3 month before this study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Efficacy of hyperpigmentation reduction property of the intervention	Week 0, 1, 2 and 4	Measured the melanin index of the hyperpigmented area
Safefty profile of the intervention	Week 1, 2 and 4	Record and collect the adverse effect from the usage of the interventional cream

Secondary Outcome Measures

Name	Time	Method
Efficacy of erythema reduction property of the intervention	Week 0, 1, 2 and 4	Measured the erythema index of the hyperpigmented area
Efficacy of skin hydration property of the intervention	Week 0, 1, 2 and 4	Measured the skin hydration value of the hyperpigmented area

Trial Locations

Locations (1)

Mae Fah Luang University; 🇹🇭 Muang, Chiang Rai, Thailand

Mae Fah Luang University

🇹🇭Muang, Chiang Rai, Thailand