EUCTR2020-004802-70-FR进行中（未招募）1 期
Impact of post-ARDS COVID sedation on late neuroinflammation - PET-DEXDO COVID
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 入组人数
- 62
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- All
入选标准
- •Adult patient (age = 18 years at the time of inclusion) under 75 years old
- •COVID-19 infection documented by nasopharyngeal pCR test.
- •High affinity homozygous TPSO genotyping for the radiotracer or heterozygous intermediate affinity for the radiotracer
- •Patient who was hospitalized in intensive care for an ARDS following the COVID infection requiring mechanical ventilation and deep sedation for at least 48 hours.
- •Patient alive 12 months (+/- 3 months) after discharge from intensive care
- •Signature of free and informed consent
- •Patient affiliated to a social security scheme, excluding AME (state medical aid)
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range 31
- •F.1.3 Elderly (>=65 years) yes
- •F.1.3.1 Number of subjects for this age range 31
排除标准
- •Protected adult (under legal protection, under guardianship or curatorship)
- •Pregnancy or breast-feeding
- •Allergy to dexmedetomidine
- •Contraindication to a PET or MRI examination
- •Severe renal failure
- •(creatinine clearance <30 ml / min)
- •Serious neurological history on admission to intensive care:
- •o Severe head trauma
- •o Insane state with loss of autonomy
研究者
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