Obstacles and Levers of the Therapeutic Adherence of Multiple Sclerosis Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Multiple Sclerosis
- Sponsor
- Lille Catholic University
- Enrollment
- 153
- Locations
- 4
- Primary Endpoint
- Therapeutic adherence evaluated by a Likert scale
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
The goal of this study is to assess the role of sociocognitive and interpersonal factors in the therapeutic adherence of multiple sclerosis patients. This study will provide a better understanding of the socio-psychological issues associated with different types of non-adherence to treatment, and identify the risk factors and vulnerability of each patient.
Detailed Description
Multiple sclerosis is a chronic and progressive disease that affects young adults (between 20 and 40 years old), impacting significantly the patients quality of life. The adherence to therapy affects the long-term functional clinical course (lower risk of relapses, reduction in disability progression and quality of life). The non-adherence rate to therapy in multiple sclerosis is estimated at 40%. The main identified causes of non-adherence are: forgetting to take treatment and adverse effects of drugs. Sociocognitive models as the Theory of Planned Behaviour (TPB) have been developed to help to understand and predict health-related behaviours. This model postulates that the intention to adopt a behaviour is one of the major determinants in the context of health. This intention comes from three independent elements : * Personal positive or negative attitudes towards the behaviour, * Social expectations or entourage perception (subjective norms), * Difficulty in accomplishing this behaviour (perceived control) Multiple sclerosis adherence to therapy studies have mainly focused on somatic variables (physical disability, illness duration, type of treatment) and some clinical variables (cognitive impairment, fatigue, depression). The few studies that have examined the multiple sclerosis therapeutic adherence determinants have mainly taken a one-dimensional perspective, such as perceived control. In the FELSA-SEP study, the role of sociocognitive factors (norms and beliefs, perceived threat to disease and health behaviours) and interpersonal factors (social support, patient-doctor relationship) will be explored.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Multiple sclerosis defined according to McDonald criteria;
- •Already undergone or beginning substantive treatment (self-managed, excluding treatment administered in hospital)
- •Aged ≥ 18 years;
- •Given the informed consent form.
Exclusion Criteria
- •Severe cognitive impairment (score below the 5th percentile);
- •Any associated neurological pathology or serious or chronic somatic disease (cancer);
- •Being under a legal protection measure.
Outcomes
Primary Outcomes
Therapeutic adherence evaluated by a Likert scale
Time Frame: 6 months
This 19-item self-questionnaire provides 5 sub-scores corresponding to each of the sub-dimensions (Attitudes, Subjective norms, Perception of control, Behavioural intention and Behaviour) and an overall score (sum of the 5 sub-scores).
Secondary Outcomes
- Handicap will be evaluated by the Expanded Disability Status Scale (EDSS)(3 weeks)
- Relapses number(3 weeks)
- Personality traits measured by the Big Five Inventory-FR questionnaire (BFI-FR)(3 weeks)
- Cognitive disorders through the SDMT (Symbol Digit Modalities Test)(3 weeks)
- Perceived interpersonal relationships quality measure by the perceived social support questionnaire (QSSP)(6 months)
- Anxiety-depressive symptoms measured by the Hospital Anxiety and Depression Scale (HADS)(3 weeks)
- Perceived threat measured with a self-assessment form(3 weeks)
- Perceived interpersonal relationships quality measure by the 4-Point ordinal Alliance Scale (11-items 4-PAS)(6 months)
- Illness duration in days(3 weeks)
- Fatigue perceived through the FSS (Fatigue Severity Scale)(3 weeks)