Evaluation of correlation between radiographs and salivary alkaline phosphatase levels as skeletal maturity indicators

Recruiting

Conditions: all classes of malocclusion

Registration Number: CTRI/2020/03/024048

Lead Sponsor: Dr LINGANNAGARI SWATHI

Brief Summary: Skeletal maturity assessment plays a key role inorthodontic diagnosis and treatment planning which is commonly done usingradiographic methods like cervical vertebral maturation and hand-wristradiographs, which involves additional radiation exposure.

Newnoninvasive analysis of biological mediators such as insulin-like growthfactor-1 (IGF-1), salivary alkaline phosphatase (ALP), have been investigatedto assess skeletal maturity. Further studies have been recommended toinvestigate the role of these biomarkers in assessing growth status. Hencethe present study is taken up to evaluate if salivary alkaline phosphataselevels can be used toassess skeletal maturity

Detailed Description: Not available

Recruitment & Eligibility

Status: Open to Recruitment

Sex: Female

Target Recruitment: 66

Inclusion Criteria

Subjects in the age group of 8-16 years females will be selected who require orthodontic therapy Good general health with absence of any nutritional problems.

Exclusion Criteria

Any subject diagnosed with a medical condition systemic disease salivary gland disorders will be excluded Individuals under any medication that could affect bone metabolism during the previous 6 months for example vitamin preparations and calcium supplements.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Alkaline phosphatase levels in saliva by Calorimetry	baseline

Secondary Outcome Measures

Name	Time	Method
cervical vertebral maturation stages from lateral cephalograms	handwrist radiographs

Trial Locations

Locations (1): department of orthodontics and dentofacial orthopaedics
🇮🇳
Nalgonda, TELANGANA, India
department of orthodontics and dentofacial orthopaedics
🇮🇳Nalgonda, TELANGANA, India
LINGANNAGARI SWATHI
Principal investigator
8328450768
swathilingannagari17@gmail.com